昆明医科大学学报
昆明醫科大學學報
곤명의과대학학보
Journal of Kunming Medical University
2013年
12期
145-148
,共4页
陈贤玉(综述)%王昆华(审校)
陳賢玉(綜述)%王昆華(審校)
진현옥(종술)%왕곤화(심교)
乳腺癌%Her-2基因%曲妥珠单抗%靶向治疗
乳腺癌%Her-2基因%麯妥珠單抗%靶嚮治療
유선암%Her-2기인%곡타주단항%파향치료
Breast cancer%Her-2 gene%Herceptin%Targeted therapy
原癌基因的激活和抑癌基因的失活是肿瘤形成的重要分子机制。原癌基因HER-2是与乳腺癌的侵袭，转移及预后密切相关，HER-2过表达型乳腺癌进展快，预后差。近年来，针对HER-2结构构建具有靶向治疗作用的单克隆抗体药物曲妥珠单抗出现，显著提高了HER-2阳性晚期乳腺癌的疗效。
原癌基因的激活和抑癌基因的失活是腫瘤形成的重要分子機製。原癌基因HER-2是與乳腺癌的侵襲，轉移及預後密切相關，HER-2過錶達型乳腺癌進展快，預後差。近年來，針對HER-2結構構建具有靶嚮治療作用的單剋隆抗體藥物麯妥珠單抗齣現，顯著提高瞭HER-2暘性晚期乳腺癌的療效。
원암기인적격활화억암기인적실활시종류형성적중요분자궤제。원암기인HER-2시여유선암적침습，전이급예후밀절상관，HER-2과표체형유선암진전쾌，예후차。근년래，침대HER-2결구구건구유파향치료작용적단극륭항체약물곡타주단항출현，현저제고료HER-2양성만기유선암적료효。
Oncogene activation and inactivation of tumor suppressor genes is an important molecular mechanism of tumor formation. HER-2 oncogene is associated with breast cancer invasion and metastasis and prognosis, HER-2 overexpressing breast cancer progresses rapidly and has poor prognosis. In recent years, the emergence of targeted therapeutic monoclonal antibody drug Herceptin which built its structure for the HER-2 has significantly inproved HER-2-positive advanced breast cancer.
