CAJ | 학술논문

目的：通过比较2型糖尿病（T2DM）患者中幽门螺杆菌（Hp）感染阳性组与阴性组之间颈动脉斑块（CP）的发生率，探讨Hp感染与T2DM患者CP的相关性以及CP形成的危险因素。方法通过对195例T2DM患者进行13碳尿素呼气试验（13C-UBT）以评估Hp感染与否，将患者分为感染组及非感染组，并进一步将试验组分为轻度感染组、中度感染组和重度感染组，运用彩色多普勒超声仪了解各组颈动脉斑块（CP）情况，同时测定各组患者HCY、LDL、Fbg、TC、Hs-CRP水平进行比较。结果 Hp感染组其颈动脉斑块的发病率大于Hp感染阴性组（P＜0.05）；感染组和非感染组Hs-CRP的差异有统计学意义（P＜0.05）；Logistic回归分析显示：Hp感染是T2DM患者发生CP的危险因素之一；Hp感染程度对CP检出率无影响。结论幽门螺杆菌感染阳性的T2DM患者可能有更高的颈动脉斑块发生率，这一结果与HCY、LDL、Fbg、TC水平无关；Hp感染是T2DM患者发生CP的危险因素；Hp感染的严重程度对T2DM患者的CP发生率无明显影响。
목적：통과비교2형당뇨병（T2DM）환자중유문라간균（Hp）감염양성조여음성조지간경동맥반괴（CP）적발생솔，탐토Hp감염여T2DM환자CP적상관성이급CP형성적위험인소。방법통과대195례T2DM환자진행13탄뇨소호기시험（13C-UBT）이평고Hp감염여부，장환자분위감염조급비감염조，병진일보장시험조분위경도감염조、중도감염조화중도감염조，운용채색다보륵초성의료해각조경동맥반괴（CP）정황，동시측정각조환자HCY、LDL、Fbg、TC、Hs-CRP수평진행비교。결과 Hp감염조기경동맥반괴적발병솔대우Hp감염음성조（P＜0.05）；감염조화비감염조Hs-CRP적차이유통계학의의（P＜0.05）；Logistic회귀분석현시：Hp감염시T2DM환자발생CP적위험인소지일；Hp감염정도대CP검출솔무영향。결론유문라간균감염양성적T2DM환자가능유경고적경동맥반괴발생솔，저일결과여HCY、LDL、Fbg、TC수평무관；Hp감염시T2DM환자발생CP적위험인소；Hp감염적엄중정도대T2DM환자적CP발생솔무명현영향。
Objective By comparing the incidence of Carotid plaques(CP) in Helicobacter pylori (Hp) infection-positive group(experimental group) and negative group (control group), this paper explored the correlation between Hp infection and CP In patients with type 2 diabetes mellitus(T2DM), and to analyze the related factors of CP. Methods 13C-Urea Breath Test (13C-UBT) was used to assess Hp infection or not. Based on the results of the breath test, a total of 195 patients with T2DM were divided into infection-positive group and infection-negative group. The experimental group was further divided into mild infection, moderate infection and severe infection. Color Doppler ultrasonography was used in each group to detect CP and to measure HCY, LDL, FBG, TC and Hs-CRP for comparison. Results The incidence rate of CP was greater in HP infection-positive group compared to Hp infection-negative group(P<0.05). The difference of Hs-CRP in the infection-positive group and infection-negative group was statistically significant(P<0.05). Logistic regression analysis showed that HP infection was correlated with CP in patients with T2DM. The severity of HP infection has no significant effect on the incidence of CP. Conclusion Helicobacter pylori infection-positive patients with T2DM may have a higher incidence of carotid plaque, regardless of HCY, LDL, FBG and TC level. This study showed that HP was correlated with CP.The severity of HP infection has no significant effect on the incidence of CP.