CAJ | 학술논문

目的：研究母婴规范诊治对于先天性梅毒患儿RPR转变的影响。方法：对我院收治的72例梅毒孕妇及所产新生儿的临床资料进行分析，按照孕妇梅毒诊治是否规范将新生儿分为A组（规范诊治组）和B组（非规范诊治组），比较两组孕妇的妊娠结局及新生儿快速血浆反应素环状卡片试验（RPR）阳性率，比较两组新生儿的临床表现，观察两组患儿的RPR的转变情况。结果：A组孕妇的足月分娩率（92.5％）、新生儿的RPR阳性率（55.0％）与B组相比，差异有统计学意义（P＜0.05）；B组新生儿，出现皮肤损伤、病理性黄疸等临床症状的比率明显高于A组，差异具有统计学意义（P＜0.05）；经治疗后A组患儿的转阴时间更短，治疗到12个月，两组患儿全部转阴。结论：梅毒孕妇进行规范化诊治后，所产先天性梅毒患儿几率下降，且先天性梅毒患儿RPR转阴更快。
목적：연구모영규범진치대우선천성매독환인RPR전변적영향。방법：대아원수치적72례매독잉부급소산신생인적림상자료진행분석，안조잉부매독진치시부규범장신생인분위A조（규범진치조）화B조（비규범진치조），비교량조잉부적임신결국급신생인쾌속혈장반응소배상잡편시험（RPR）양성솔，비교량조신생인적림상표현，관찰량조환인적RPR적전변정황。결과：A조잉부적족월분면솔（92.5％）、신생인적RPR양성솔（55.0％）여B조상비，차이유통계학의의（P＜0.05）；B조신생인，출현피부손상、병이성황달등림상증상적비솔명현고우A조，차이구유통계학의의（P＜0.05）；경치료후A조환인적전음시간경단，치료도12개월，량조환인전부전음。결론：매독잉부진행규범화진치후，소산선천성매독환인궤솔하강，차선천성매독환인RPR전음경쾌。
Objectives:To investigate the influence of standardized maternal diagnosis and treatment on the RPR results of newborns with congenital syphilis.Method:We studied the clinical information of 72 gravidae with syphilis and their newborn babies,and divided them into group A (the standardized group)and group B (the un-standardized group).Then we compared the pregnancy outcomes of gravidae,the rapid plasma reagin test (RPR) positive rates and clinical presentations of newborns,and observed the changes of RPR results.Results:The term delivery rate (92.5%)and neonatal RPR positive rate (55.0%)in group A were significantly higher that those in group B (P<0.05),while the incidence of skin damage,pathological jaundice and other clinical symptoms of group B were significantly higher than those in group A (P<0.05).As for group A,shorter time was taken for the RPR results to turn from positive to negative after the treatment,and all RPR became negative after 12 -month treatment.Conclusion:Standardized diagnosis and treatment for gravidae with syphilis was helpful to reduce the in-cidence of neonatal congenital syphilis and to decrease the time taken for the RPR results to turn negative.