CAJ | 학술논문

背景：白细胞介素6作为一种重要的细胞因子，在炎症部位调节了免疫反应并可通过自分泌和旁分泌的方式刺激破骨细胞的形成和骨吸收，与正畸牙移动骨改建相关。 　　目的：观察正畸力对大鼠牙周组织中白细胞介素6 mRNA表达的影响。 　　方法：建立大鼠正畸牙移动模型并运用原位杂交法观测加力后1，3，5，7，10，14 d白细胞介素6 mRNA在各组大鼠牙周组织内的表达情况。 　　结果与结论：正常大鼠牙周组织内白细胞介素6 mRNA 呈弱阳性表达；加力组大鼠牙周组织内白细胞介素6mRNA 的表达在加力后3 d 达到高峰，之后开始下降。实验提示正畸力虽可引起局部牙周组织白细胞介素6mRNA 的表达增强，但具有一定的自限性。白细胞介素6作为多功能细胞因子，在正畸牙移动牙周改建中起重要作用。
배경：백세포개소6작위일충중요적세포인자，재염증부위조절료면역반응병가통과자분비화방분비적방식자격파골세포적형성화골흡수，여정기아이동골개건상관。 　　목적：관찰정기력대대서아주조직중백세포개소6 mRNA표체적영향。 　　방법：건립대서정기아이동모형병운용원위잡교법관측가력후1，3，5，7，10，14 d백세포개소6 mRNA재각조대서아주조직내적표체정황。 　　결과여결론：정상대서아주조직내백세포개소6 mRNA 정약양성표체；가력조대서아주조직내백세포개소6mRNA 적표체재가력후3 d 체도고봉，지후개시하강。실험제시정기력수가인기국부아주조직백세포개소6mRNA 적표체증강，단구유일정적자한성。백세포개소6작위다공능세포인자，재정기아이동아주개건중기중요작용。
BACKGROUND:As an important cytokine, interleukin-6 regulates immune responses in inflammation sites and has an autocrine/paracrine activity that stimulates osteoclast formation and bone resorption, which is related to bone remodeling during orthodontic tooth movement. OBJECTIVE:To investigate the effects of orthodontic force on the expression of interleukin-6 mRNA in the periodontal tissue of rats. METHODS:In situ hybridization was performed to measure the expression of interleukin-6 mRNA at 1, 3, 5, 7, 10 and 14 days after the application of orthodontic force on the maxil ary first molars of rats. RESULTS AND CONCLUSION:The expression of interleukin-6 mRNA was observed at a low level in the normal periodontal tissue of rats. After the application of force, the induction of interleukin-6 mRNA was observed to reach a maximum on day 3 and to decline thereafter. The expression of interleukin-6 mRNA can be evoked by orthodontic force but with a certain self-limiting. As a multifunctional cytokine, interleukin-6 plays a very important role in periodontal remodeling during orthodontic tooth movement.