CAJ | 학술논문

背景：富血小板血浆内含有的生长因子能够促进骨-腱愈合，从而减少了前交叉韧带重建后骨隧道扩大的发生；不同浓度的富血小板血浆对骨隧道的扩大有一定的影响，但是目前尚不清楚何种浓度更佳。 　　目的：观察富血小板血浆对前交叉韧带重建后隧道扩大的影响。 　　方法：将20只新西兰大白兔，参照Martinek等的方法进行兔的双侧前交叉韧带重建。在一侧肢体的肌腱移植物给予10 mg富血小板血浆凝胶预处理作为观察组，对侧肢体移植物给予5 mg富血小板血浆凝胶预处理为对照组。处理后12周进行影像学观察以及测量骨隧道的宽度，计算隧道扩大率。 　　结果与结论：在前交叉韧带重建后的8周、12周的时间点上，10 mg富血小板血浆组隧道扩大的宽度小于5 mg富血小板血浆组(P <0.05)；10 mg富血小板血浆组的腱-骨结合部位的骨密度值大于5 mg富血小板血浆组(P <0.05)。提示富血小板血浆能够促进兔前交叉韧带重建后腱-骨界面骨密度的提高，有效预防骨隧道的扩大，且以富血小板血浆浓度10 mg为佳。
배경：부혈소판혈장내함유적생장인자능구촉진골-건유합，종이감소료전교차인대중건후골수도확대적발생；불동농도적부혈소판혈장대골수도적확대유일정적영향，단시목전상불청초하충농도경가。 　　목적：관찰부혈소판혈장대전교차인대중건후수도확대적영향。 　　방법：장20지신서란대백토，삼조Martinek등적방법진행토적쌍측전교차인대중건。재일측지체적기건이식물급여10 mg부혈소판혈장응효예처리작위관찰조，대측지체이식물급여5 mg부혈소판혈장응효예처리위대조조。처리후12주진행영상학관찰이급측량골수도적관도，계산수도확대솔。 　　결과여결론：재전교차인대중건후적8주、12주적시간점상，10 mg부혈소판혈장조수도확대적관도소우5 mg부혈소판혈장조(P <0.05)；10 mg부혈소판혈장조적건-골결합부위적골밀도치대우5 mg부혈소판혈장조(P <0.05)。제시부혈소판혈장능구촉진토전교차인대중건후건-골계면골밀도적제고，유효예방골수도적확대，차이부혈소판혈장농도10 mg위가。
BACKGROUND:Platelet-rich plasma contains growth factors that can promote tendon-bone healing, thereby reducing occurrence of bone tunnel enlargement after anterior cruciate ligament reconstruction;different concentrations of platelet-rich plasma have certain influence on bone tunnel enlargement, but it is not clear which concentration is optimal. OBJECTIVE:To study the effect of platelet-rich plasma on tunnel enlargement after anterior cruciate ligament reconstruction. METHODS:Bilateral anterior cruciate ligament reconstruction was conducted in 20 New Zealand white rabbits using Martinek et al’s method. Tendon graft was pretreated with 10 mg platelet-rich plasma gel on one side as an observation group. Graft on the contralateral limb was pretreated with 5 mg platelet-rich plasma gel as control group. At 12 weeks after surgery, radiological observation and measure of the width of bone tunnel were conducted. Tunnel enlargement rate was calculated. RESULTS AND CONCLUSION:At 8 and 12 weeks after anterior cruciate ligament reconstruction, the width of tunnel enlargement was less in the 10 mg-platelet-rich plasma group than that in the 5 mg-platelet-rich plasma group (P<0.05). Bone density of tendon-bone interface was larger in the 10 mg-platelet-rich plasma group than that in the 5 mg-platelet-rich plasma group (P<0.05). These results indicated that platelet-rich plasma promoted in bone density of tendon-bone interface after rabbit anterior cruciate ligament reconstruction, effectively prevented enlargement of bone tunnel. Moreover, 10 mg platelet-rich plasma is perfect.