CAJ | 학술논문

背景：目前临床上应用的心脏生物瓣和机械瓣都存在一些缺陷和不足，而组织工程心脏瓣膜有可能避免这些问题的出现，成为瓣膜替代物的理想选择。 　　目的：探讨构建组织工程心脏瓣膜的实验研究进展。 　　方法：应用数据库检索的方法分析关于组织工程心脏瓣膜的实验研究文献，组织工程心脏瓣膜的三大要素为种子细胞、支架材料和细胞种植。 　　结果与结论：心脏瓣膜修复和置换是目前治疗心脏瓣膜性疾病的主要外科手段。目前，主要用于构建组织工程心脏瓣膜的种子细胞有血管内皮细胞、内皮祖细胞以及骨髓间充质干细胞等。经脱细胞处理的支架具有良好的生物力学性能和组织相容性，细胞种植后支架表面会形成一层连续的细胞层，其构建的组织工程心脏瓣膜是可行的。组织工程心脏瓣膜有着良好的应用前景，但目前还有很多问题需要解决，还处于研究的初级阶段。
배경：목전림상상응용적심장생물판화궤계판도존재일사결함화불족，이조직공정심장판막유가능피면저사문제적출현，성위판막체대물적이상선택。 　　목적：탐토구건조직공정심장판막적실험연구진전。 　　방법：응용수거고검색적방법분석관우조직공정심장판막적실험연구문헌，조직공정심장판막적삼대요소위충자세포、지가재료화세포충식。 　　결과여결론：심장판막수복화치환시목전치료심장판막성질병적주요외과수단。목전，주요용우구건조직공정심장판막적충자세포유혈관내피세포、내피조세포이급골수간충질간세포등。경탈세포처리적지가구유량호적생물역학성능화조직상용성，세포충식후지가표면회형성일층련속적세포층，기구건적조직공정심장판막시가행적。조직공정심장판막유착량호적응용전경，단목전환유흔다문제수요해결，환처우연구적초급계단。
BACKGROUND:Current cardiac bioprostheses and mechanical valves are shown to have some flaws and shortcomings, and tissue-engineered heart valves which can avoid these problems are becoming an ideal choice for valve replacement. OBJECTIVE:To explore the experimental progress in the construction of tissue-engineered heart valves. METHODS:Experimental studies related to tissue-engineered heart valves were retrieved in databases. Three main elements for tissue-engineered heart valves are seed cells, scaffold materials, and cellseeding. RESULTS AND CONCLUSION:Cardiac valve repair and replacement is the primarily surgical treatment for valvular heart disease. At present, seed cells mainly for construction of tissue-engineered heart valves include vascular endothelial cells, endothelial progenitor cells and bone marrow mesenchymal stem cells. The acellular scaffold has good biomechanical properties and histocompatibility. After cellseeding, a continuous celllayer wil form on the scaffold surface, which makes it possible to construct tissue-engineered heart valves. Tissue-engineered heart valve has a good prospect, but it is stil in the early stage of research and there are stil many problems that need to be solved.