CAJ | 학술논문

背景：渗透性扩张器是内含甲基丙烯酸甲脂和N-乙烯基吡咯烷酮吸水性凝胶的自膨胀扩张器，植入机体后可通过吸附体液而缓慢膨胀。 　　目的：通过大鼠皮下包埋实验，探讨渗透性扩张器在动物体内的近远期变化规律及组织相容性。 　　方法：设计Wistar大鼠自身对照实验，将渗透性扩张器(样品)和高密度聚乙烯(对照品)分别植入大鼠皮下，观察术后创面愈合情况，渗透性扩张器植入不同时间的扩张情况及其在大鼠体内的炎症反应。 　　结果与结论：所有大鼠术后创面均Ⅰ级甲等愈合；渗透性扩张器植入大鼠体内第1周膨胀速度最快，4周时可膨胀至原始体积的9倍，4周后膨胀速度逐渐减慢，至12周体积约为原始体积的10倍，而后维持此体积不变；病理切片显示，渗透性扩张器植入后的炎症反应与高密度聚乙烯组比较差异无显著性意义(P>0.05)，说明渗透性扩张器具有缓慢持久的吸水膨胀能力及良好的组织相容性。
배경：삼투성확장기시내함갑기병희산갑지화N-을희기필각완동흡수성응효적자팽창확장기，식입궤체후가통과흡부체액이완만팽창。 　　목적：통과대서피하포매실험，탐토삼투성확장기재동물체내적근원기변화규률급조직상용성。 　　방법：설계Wistar대서자신대조실험，장삼투성확장기(양품)화고밀도취을희(대조품)분별식입대서피하，관찰술후창면유합정황，삼투성확장기식입불동시간적확장정황급기재대서체내적염증반응。 　　결과여결론：소유대서술후창면균Ⅰ급갑등유합；삼투성확장기식입대서체내제1주팽창속도최쾌，4주시가팽창지원시체적적9배，4주후팽창속도축점감만，지12주체적약위원시체적적10배，이후유지차체적불변；병리절편현시，삼투성확장기식입후적염증반응여고밀도취을희조비교차이무현저성의의(P>0.05)，설명삼투성확장기구유완만지구적흡수팽창능력급량호적조직상용성。
BACKGROUND:The osmotic tissue expander is a self-fil ing device consisting of an osmotic active hydrogel which is made of vinylpyrrolidone and mehtylmethacrylate. It can absorb body fluids and swel up gradual y after embedded. OBJECTIVE:To explore the short-term and long-term regular patterns as wel as histocompatibility of the osmotic tissue expander in vivo. METHODS:A self-control design was carried out in Wistar rats by embedding the osmotic tissue expander and high-density polyethylene into each side of their spinal column subcutaneously. Wound healing, tissue expansion and inflammatory reaction were detected and compared at different periods after operation. RESULTS AND CONCLUSION:Al the wounds got primary healing. The device expanded fastest at week 1 after the implantation. After being enlarged to about nine times that of the initial size at week 4, the expander slowed down its swel ing. It reached its ultimate volume at week 12 which was about 10 times as big as that of the initial one. Then it remained almost the same size until the end of our design. Pathological sections showed that the inflammatory reaction of osmotic-tissue-expander-group had no significant difference from that of the control group (P>0.05). These findings suggest that osmotic tissue expander has a slow-lasting swel ing ability and good histocompatibility.