CAJ | 학술논문

背景：寻找具备生物力学性能与生物活性，椎体外渗漏率低的新型椎体填充材料已经成为研究的焦点。 　　目的：观察植入可降解高分子网状球囊并灌注磷酸钙骨水泥椎体的生物力学性能及骨水泥渗漏率。 　　方法：将32个猪单椎体标本随机分为4组，其中2组分别经单侧椎弓根注入2.5-3.0 mL聚甲基丙烯酸树脂骨水泥、2.5-3.0 mL磷酸钙骨水泥；其中1组首先植入可降解高分子网状球囊，然后填充2.5-3.0 mL磷酸钙骨水泥；最后1组为正常椎体。观察各组椎体的骨水泥外漏情况，经SCHENCK RSA-250电子万能试验机测试各组椎体的刚度及强度。 　　结果与结论：聚甲基丙烯酸树脂骨水泥组椎体强度及刚度明显高于正常椎体(P<0.05)，磷酸钙骨水泥组椎体强度及刚度明显低于正常椎体(P<0.05)，可降解高分子网状球囊联合骨水泥组椎体强度及刚度接近正常椎体(P>0.05)，可降解高分子网状球囊联合骨水泥组骨水泥渗漏率较聚甲基丙烯酸树脂骨水泥组与磷酸钙骨水泥组降低(P<0.05)。表明植入可降解高分子网状球囊联合磷酸钙骨水泥椎体的生物力学性能最接近正常椎体，骨水泥渗漏率校低。
배경：심조구비생물역학성능여생물활성，추체외삼루솔저적신형추체전충재료이경성위연구적초점。 　　목적：관찰식입가강해고분자망상구낭병관주린산개골수니추체적생물역학성능급골수니삼루솔。 　　방법：장32개저단추체표본수궤분위4조，기중2조분별경단측추궁근주입2.5-3.0 mL취갑기병희산수지골수니、2.5-3.0 mL린산개골수니；기중1조수선식입가강해고분자망상구낭，연후전충2.5-3.0 mL린산개골수니；최후1조위정상추체。관찰각조추체적골수니외루정황，경SCHENCK RSA-250전자만능시험궤측시각조추체적강도급강도。 　　결과여결론：취갑기병희산수지골수니조추체강도급강도명현고우정상추체(P<0.05)，린산개골수니조추체강도급강도명현저우정상추체(P<0.05)，가강해고분자망상구낭연합골수니조추체강도급강도접근정상추체(P>0.05)，가강해고분자망상구낭연합골수니조골수니삼루솔교취갑기병희산수지골수니조여린산개골수니조강저(P<0.05)。표명식입가강해고분자망상구낭연합린산개골수니추체적생물역학성능최접근정상추체，골수니삼루솔교저。
BACKGROUND:It has become a focus to look for new vertebral body fil ing materials which have the biomechanical property, biological activity and low cement leakage rate. OBJECTIVE:To investigate the biomechanical characters and cement leakage rate of the vertebral bodies implanted with biodegradable reticulated bal oon and calcium phosphate. METHODS:Thirty-two vertebral bodies from pigs were randomly divided to four groups. For A group, 2.5-3.0 mL polymethacrylate cement was injected into the body through a unilateral thoracic pedicle pathway;for B group, 2.5-3.0 mL calcium phosphate cement were injected by the same protocol;for C group, the biodegradable reticulated bal oons fil ed with 2.5-3.0 mL calcium phosphate cement were implanted;D group, including normal vertebral bodies, was designed as controls. Leakage of bone cement was observed in each group. The load-shift curves were recorded by an electronic universal testing machine (SCHENCK RSA-250). RESULTS AND CONCLUSION:The stiffness and strength of A group were significantly higher than those of D group (P<0.05), and the stiffness and strength of B group were statistical y lower than those of D group (P<0.05). The stiffness and strength of C group, otherwise, were similar with those of D group (P>0.05). Cement leakage rate of C group was lower than that of A or B group (P<0.05). Vertebral bodies implanted with biodegradable reticulated bal oons may lead to similar biomechanical characters as the normal vertebral bodies and reduce the cement leakage rate.