中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2014年
4期
67-69
,共3页
复发性生殖器疱疹%卡介菌多糖核酸%泛昔洛韦%复发
複髮性生殖器皰疹%卡介菌多糖覈痠%汎昔洛韋%複髮
복발성생식기포진%잡개균다당핵산%범석락위%복발
Recurrent Genital Herpes (RGH)%BCG-PSN%Famciclovir%Reoccurrence
目的：探讨卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹的疗效及预防复发作用。方法：选择70例复发性生殖器疱疹随机分为两组（对照组与联合组）。两组均予以口服泛昔洛韦片0.25 g，2次/d，连用10d；后改为0.125g，2次/d，整个疗程共3个月。联合组在此基础上予以卡介菌多糖核酸1mL肌注，2次/周，连用3个月。对照组患者仅予以口服泛昔洛韦，剂量及疗程同联合组。观察两组患者治疗后临床效果及药物不良反应，并随访治疗结束后半年及1年内的复发率。结果：联合组治疗后临床总有效率为77.14％，明显高于对照组的42.86％（χ2＝8.57，P＜0.01）。联合组和对照组治疗期间出现药物不良反应6例和4例，症状均较轻，两组比较无统计学差异（χ2＝0.47，P＞0.05）。治疗结束后对治疗有效者均随访半年及1年内的复发率，联合组的复发率均明显低于对照组（P＜0.05或P＜0.01）。结论：卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹取得了较好效果，不良反应轻，并可降低其复发率，具有治疗和预防复发双重作用。
目的：探討卡介菌多糖覈痠聯閤汎昔洛韋治療複髮性生殖器皰疹的療效及預防複髮作用。方法：選擇70例複髮性生殖器皰疹隨機分為兩組（對照組與聯閤組）。兩組均予以口服汎昔洛韋片0.25 g，2次/d，連用10d；後改為0.125g，2次/d，整箇療程共3箇月。聯閤組在此基礎上予以卡介菌多糖覈痠1mL肌註，2次/週，連用3箇月。對照組患者僅予以口服汎昔洛韋，劑量及療程同聯閤組。觀察兩組患者治療後臨床效果及藥物不良反應，併隨訪治療結束後半年及1年內的複髮率。結果：聯閤組治療後臨床總有效率為77.14％，明顯高于對照組的42.86％（χ2＝8.57，P＜0.01）。聯閤組和對照組治療期間齣現藥物不良反應6例和4例，癥狀均較輕，兩組比較無統計學差異（χ2＝0.47，P＞0.05）。治療結束後對治療有效者均隨訪半年及1年內的複髮率，聯閤組的複髮率均明顯低于對照組（P＜0.05或P＜0.01）。結論：卡介菌多糖覈痠聯閤汎昔洛韋治療複髮性生殖器皰疹取得瞭較好效果，不良反應輕，併可降低其複髮率，具有治療和預防複髮雙重作用。
목적：탐토잡개균다당핵산연합범석락위치료복발성생식기포진적료효급예방복발작용。방법：선택70례복발성생식기포진수궤분위량조（대조조여연합조）。량조균여이구복범석락위편0.25 g，2차/d，련용10d；후개위0.125g，2차/d，정개료정공3개월。연합조재차기출상여이잡개균다당핵산1mL기주，2차/주，련용3개월。대조조환자부여이구복범석락위，제량급료정동연합조。관찰량조환자치료후림상효과급약물불량반응，병수방치료결속후반년급1년내적복발솔。결과：연합조치료후림상총유효솔위77.14％，명현고우대조조적42.86％（χ2＝8.57，P＜0.01）。연합조화대조조치료기간출현약물불량반응6례화4례，증상균교경，량조비교무통계학차이（χ2＝0.47，P＞0.05）。치료결속후대치료유효자균수방반년급1년내적복발솔，연합조적복발솔균명현저우대조조（P＜0.05혹P＜0.01）。결론：잡개균다당핵산연합범석락위치료복발성생식기포진취득료교호효과，불량반응경，병가강저기복발솔，구유치료화예방복발쌍중작용。
Objectives:To discuss the curative effect and reoccurrence prevention of BCG-PSN combined with Famciclovir on the treatment of Recurrent Genital Herpes (RGH).Method:70 cases of patients with RGH were selected and divided into the control group and the experiment group randomly.All the patients were given Famciclovir tablets for 0.25g twice a day for 10 days.For the next course of 3 months,the dosage was changed to 0.125g twice a day.The patients of the experiment group were additionally given 1mL of BCG-PSN by intramuscu-lar injection twice a week for 3 months,while the patients in the control group only took Famciclovir with the same dosage orally.The clinical curative effect,drug adverse reaction,half-a-year reoccurrence rate and one-year reoccurrence rate of the patients in the 2 groups were observed and compared after the treatment.Results:The total clinical efficiency rate of patients in the combined group was 77.14%,which was much higher than that (42.86%)in control group (χ2 =8.57,P<0.01 ).There were 6 and 4 cases showing adverse reactions in experiment group and control group respectively,with no statistical differences (χ2 =0.47,P>0.05).The reoccurrence rate of patients in the experiment group was much lower than that in control group (P <0.05 or P <0.01 ). Conclusion:BCG-PSN combined with Famciclovir has reliable curative effect on the treatment of recurrent Genital Herpes (RGH).It produces less adverse reactions and low reoccurrence rate.
