CAJ | 학술논문

目的：了解龙岩市妇女宫颈 H PV感染情况及 H PV基因亚型分布情况，为预防和治疗宫颈癌提供有价值的参考资料。方法：运用导流杂交基因芯片技术对2335例患者的宫颈分泌物标本进行21种 H PV基因亚型检测，并对2335例标本的 H PV 基因亚型感染情况进行对比分析。结果：自2335例宫颈分泌物标本中，共计检出563例 H PV呈阳性的标本，感染率为24．11％。在563例阳性标本中， H PV高危基因亚型感染频度的前5位依次为：H PV-52、-16、-58、-33及-31，阳性率分别为：26．82％、20．96％、13．68％、11．55％和5．86％。30～50岁是 HPV感染的高峰年龄段，HPV阳性检出率在各年龄组的差异有统计学意义（P＜0．05）。结论：运用导流杂交基因芯片技术进行 HPV基因分型检测对宫颈癌预防和治疗有较好的指导意义。
목적：료해룡암시부녀궁경 H PV감염정황급 H PV기인아형분포정황，위예방화치료궁경암제공유개치적삼고자료。방법：운용도류잡교기인심편기술대2335례환자적궁경분비물표본진행21충 H PV기인아형검측，병대2335례표본적 H PV 기인아형감염정황진행대비분석。결과：자2335례궁경분비물표본중，공계검출563례 H PV정양성적표본，감염솔위24．11％。재563례양성표본중， H PV고위기인아형감염빈도적전5위의차위：H PV-52、-16、-58、-33급-31，양성솔분별위：26．82％、20．96％、13．68％、11．55％화5．86％。30～50세시 HPV감염적고봉년령단，HPV양성검출솔재각년령조적차이유통계학의의（P＜0．05）。결론：운용도류잡교기인심편기술진행 HPV기인분형검측대궁경암예방화치료유교호적지도의의。
Objective :To investigate the status of HPV infection and distribution of HPV genotypes in women in longyan Area and provide valuable data for preventing and treating uterine cervical cancer .Methods :A total of 21 kinds of HPV genotypes infection were detected by flow-through hybridization and gene chip technique among 2 335 women , the infections status of subtypes of HPV were compared and analyzed Results:Among 2 335 cases ,563 cases were infec-ted HPV ,with the positive rate of 24 .11% .Among 563 cases ,the top five high-risk Subtypes of HPV were HPV-52 (26 .82% ) ,-16(20 .96% ) ,-58(13 .68% ) ,-33(11 .55% ) and-31(5 .86% ) .The peak age of HPV infection ranged from 30 to 50 years old .There were statistical significance among the HPV positive rates in different age groups (P<0.05) . Conclusion:HPV genotyping detection is meaningful for preventing and treating uterine cervical cancer .