CAJ | 학술논문

目的：调查贵州省苗族、布依族及汉族EB病毒感染情况并探讨EB病毒特异性Zta-IgA、EBNA1-IgA与VCA-IgA抗体定量检测对鼻咽癌的诊断价值。方法采用随机抽样的方法抽取苗族、布依族及汉族共3040例研究对象，收集研究对象的基本信息；采用 ELISA法检测研究对象血浆EB病毒的Zta-IgA、EBNA1-IgA、VCA-IgA标志物水平，分析上述指标诊断鼻咽癌的价值。结果3040例研究对象中，Zta-IgA阳性率为15．03％；EBNA1-IgA阳性率为16．09％；VCA-IgA阳性率为14．41％（χ2＝16．027， P＝0．000）；Zta-IgA、EBNA1-IgA、VCA-IgA 阳性率均为布依族最高（P＜0．05）；＞45岁组Zta-IgA、EBNA1-IgA、VCA-IgA阳性率均明显高于≤45岁年龄组（P＜0．05）；吸烟、饮酒可以明显提高Zta-IgA、EBNA1-IgA、VCA-IgA阳性率（P＜0．05）；三者联合检测对诊断鼻咽癌的灵敏度和特异度均明显升高。结论贵州省少数民族 EB感染率水平较高，应开展Zta-IgA、EB-NA1-IgA、VCA-IgA监测；三者联合检测对鼻咽癌的早监测、早发现有积极意义。
목적：조사귀주성묘족、포의족급한족EB병독감염정황병탐토EB병독특이성Zta-IgA、EBNA1-IgA여VCA-IgA항체정량검측대비인암적진단개치。방법채용수궤추양적방법추취묘족、포의족급한족공3040례연구대상，수집연구대상적기본신식；채용 ELISA법검측연구대상혈장EB병독적Zta-IgA、EBNA1-IgA、VCA-IgA표지물수평，분석상술지표진단비인암적개치。결과3040례연구대상중，Zta-IgA양성솔위15．03％；EBNA1-IgA양성솔위16．09％；VCA-IgA양성솔위14．41％（χ2＝16．027， P＝0．000）；Zta-IgA、EBNA1-IgA、VCA-IgA 양성솔균위포의족최고（P＜0．05）；＞45세조Zta-IgA、EBNA1-IgA、VCA-IgA양성솔균명현고우≤45세년령조（P＜0．05）；흡연、음주가이명현제고Zta-IgA、EBNA1-IgA、VCA-IgA양성솔（P＜0．05）；삼자연합검측대진단비인암적령민도화특이도균명현승고。결론귀주성소수민족 EB감염솔수평교고，응개전Zta-IgA、EB-NA1-IgA、VCA-IgA감측；삼자연합검측대비인암적조감측、조발현유적겁의의。
Objective To investigate EB virus infection of Miao ,Buyi and Han population and e-valuate the diagnosis of Zta-IgA ,EBNA1-IgA and VCA-IgA antibody for nasopharyngeal carcinoma in Guizhou Province .Methods A random sampling method was used to select 3040 subjects from Miao , Buyi and Han ,collecting basic information .ELISA was used to detected serum Zta-IgA ,EBNA1-IgA ,VCA-IgA of EB virus for analysing the value of these indicators diagnosis of NPC .Results Zta-IgA positive rate was 15 .03% .EBNA1-IgA-positive rate was 16 .09% .VCA1-IgA-positive rate was 14 .41% (χ2 = 16 .027 ,P= 0 .000) .Zta-IgA ,EBNA1-IgA ,VCA-IgA-positive rate of Buyi was the highest (P<0 .05) .Zta-IgA ,EBNA1-IgA ,VCA-IgA-positive rate of > 45 age group was signifi-cantly higher than that of ≤ 45 age group (P<0 .05) .Smoking ,alcohol could significantly increase Zta-IgA ,EBNA1-IgA ,VCA-IgA-positive rate (P<0 .05) .Combined detection of Zta-IgA ,EBNA1-IgA ,VCA-IgA could significantly increase the sensitivity and specificity for diagnosis of NPC .Conclu-sion EB prevalence of minority in Guizhou is high and Zta-IgA ,EBNA1-IgA ,VCA-IgA monitoring should be carried out ;There is positive significance of combined detection of three to the early monito-ring ,early detection of nasopharyngeal carcinoma .