CAJ | 학술논문

目的：探讨肝脏CT灌注成像对HIV合并HCV感染者早期肝硬化诊断的应用价值。方法对33例HIV感染并慢性丙型肝炎患者行肝脏CT灌注扫描，其中早期肝硬化组14例、非肝硬化组19例；对两组的各项灌注参数进行对比分析。结果早期肝硬化组与非肝硬化组对比，门静脉灌注量(HPP)、门静脉灌注指数(PPI)、肝脏总灌量(TLP)明显降低[HPP：(86.34±20.73) ml·min-1·100ml-1与(111.87±20.59) ml·min-1·100ml-1，P=0.0014；PPI：(72.18±2.94)%与(78.69±2.29)%， P=0.0001；TLP：(119.44±27.17) ml·min-1·100ml-1与(142.02±24.70) ml·min-1·100ml-1，P=0.0001]，而肝动脉灌注指数(HPI)明显升高[(27.82±2.94)%与(21.31±2.29)%， P=0.0001]；以上4项灌注参数在两组间的差异有统计学意义。结论肝脏CT灌注成像能反应HIV合并HCV早期肝硬化的血流灌注改变，对临床的早期诊断和治疗有重要价值。
목적：탐토간장CT관주성상대HIV합병HCV감염자조기간경화진단적응용개치。방법대33례HIV감염병만성병형간염환자행간장CT관주소묘，기중조기간경화조14례、비간경화조19례；대량조적각항관주삼수진행대비분석。결과조기간경화조여비간경화조대비，문정맥관주량(HPP)、문정맥관주지수(PPI)、간장총관량(TLP)명현강저[HPP：(86.34±20.73) ml·min-1·100ml-1여(111.87±20.59) ml·min-1·100ml-1，P=0.0014；PPI：(72.18±2.94)%여(78.69±2.29)%， P=0.0001；TLP：(119.44±27.17) ml·min-1·100ml-1여(142.02±24.70) ml·min-1·100ml-1，P=0.0001]，이간동맥관주지수(HPI)명현승고[(27.82±2.94)%여(21.31±2.29)%， P=0.0001]；이상4항관주삼수재량조간적차이유통계학의의。결론간장CT관주성상능반응HIV합병HCV조기간경화적혈류관주개변，대림상적조기진단화치료유중요개치。
Objective To evaluate the value of CT perfusion imaging of liver in diagnosis of the early cirrhosis in patients with HIV/HCV co-infected. Methods The CT perfusion scans of liver were tested for 33 patients with chronic hepatitis C and HIV-infected,including 14 patients with early cirrhosis and 19 patients with non-cirrhosis;parameters of the CT perfusion were compared wih two groups. Results Compared to non-cirrhosis group,HPP、PPI and TLP with patients in early cirrhosis were significant lower[HPP: (86.34±20.73)ml·min-1·100ml-1 vs (111.87±20.59) ml·min-1·100ml-1,P=0.0014; PPI:(72.18±2.94)% vs (78.69±2.29)%,P=0.0001;TLP:( 119.44±27.17)ml·min-1·100ml-1 vs (142.02±24.70)ml·min-1·100ml-1,P=0.0185], whereas their HPI were significant higher[(27.82±2.94)%vs (21.31±2.29)%,P=0.0001]. There was significant difference of the four parameters of the CT perfusion between early cirrhosis and non-cirrhosis. Conclusion The CT perfusion of liver could reflect the variation of blood flow in the patients with early cirrhosis which was co-infected with HIV/HCV.Furthermore it could be detected for early clinical diagnosis and treatment.