CAJ | 학술논문

目的：探讨TP方案（紫杉醇＋顺铂）对Ⅳ期非小细胞肺癌（ NSCLC）患者凝血功能的影响及临床意义。方法分别对40例Ⅳ期NSCLC患者及20例健康志愿者的活化部分凝血活酶时间（ aPTT）、凝血酶原时间（ PT）、纤维蛋白原（Fbg）、凝血酶时间（TT）和D二聚体（D-D）进行测定、比较。结果化疗前肺癌患者Fbg、D-D与正常对照组比较显著增高（P＜0．05）；肺癌患者化疗后与化疗前相比Fbg、D-D有显著性降低（P＜0．05）。结论Ⅳ期NSCLC患者存在凝血功能异常，TP方案化疗可改善Ⅳ期NSCLC患者的凝血功能。
목적：탐토TP방안（자삼순＋순박）대Ⅳ기비소세포폐암（ NSCLC）환자응혈공능적영향급림상의의。방법분별대40례Ⅳ기NSCLC환자급20례건강지원자적활화부분응혈활매시간（ aPTT）、응혈매원시간（ PT）、섬유단백원（Fbg）、응혈매시간（TT）화D이취체（D-D）진행측정、비교。결과화료전폐암환자Fbg、D-D여정상대조조비교현저증고（P＜0．05）；폐암환자화료후여화료전상비Fbg、D-D유현저성강저（P＜0．05）。결론Ⅳ기NSCLC환자존재응혈공능이상，TP방안화료가개선Ⅳ기NSCLC환자적응혈공능。
Objective To investigate the affecting of TP regimen ( taxol and cisplatin ) on coagulation function in patients with non-small cell lung cancer of stage Ⅳ.Methods The plasma levels of coagulation markers were detected in 40 patients with non-small cell lung cancer of stage Ⅳand 20 normal controls .Re-sults To compare with the control group ,the mean values of activated partial fibrinogen ( Fbg) and D-dimer (D-D)were significantly increase (P <0.05) in patients with NSCLC of stage Ⅳ.There was a significant difference(P<0.05) in Fbg and D-D between after chemotherapy and before chemotherapy .Conclusion Coagulation there is coagulopathy in patients with NSCLC of stage Ⅳ.TP regimen may improve the coagulation function of patients with NSCLC of stage Ⅳ.