血栓与止血学
血栓與止血學
혈전여지혈학
CHINESE JOURNAL OF THROMBOSIS AND HEMOSTASIS
2014年
4期
159-163
,共5页
高延民%刘红云%张驰%许稷豪%吴珉%李贤浩%马丽萍
高延民%劉紅雲%張馳%許稷豪%吳珉%李賢浩%馬麗萍
고연민%류홍운%장치%허직호%오민%리현호%마려평
血小板减少症%感染%病因%回顾性研究
血小闆減少癥%感染%病因%迴顧性研究
혈소판감소증%감염%병인%회고성연구
Thrombosytopenia%Infection%Causative factor%Retrospective studies
目的:探究血小板减少与感染的关系。方法回顾性分析2010年6月~2011年6月我院收治的273例急、慢性感染相关性血小板减少症(非血液系统疾病)的临床资料。结果273例中男150例,女123例,平均年龄58.2(18~96)岁。血小板计数(9~99)×109/L,平均(68.1±23.0)×109/L。引起血小板减少症的感染相关的病因分布:消化系统占40.3%(110例),呼吸系统33.7%(92例),泌尿系统6.6%(18例),神经系统2.9%(8例),皮肤2.6%(7例),五官1.8%(5例),心血管系统1.5%(4例),其他系统3.7%(10例),多系统7.0%(19例)。有明确病原学证据的感染196例(71.8%),包括病毒占28.2%(77例),细菌28.2%(77例),真菌15.4%(42例);未能明确病原体的感染28.2%(77例)。疾病伴随症状和辅助检查:发热27.1%(74例),血培养阳性8.4%(23例),痰培养阳性25.3%(69例),中性粒细胞增多24.5%(67)。细菌感染引起的血小板减少最低值较病毒感染低,差异有统计学意义(P<0.05);细菌与真菌、病毒与真菌感染引起血小板减少最低值无显著差异。结论感染相关性血小板减少症中以病毒、细菌感染最常见,其次为真菌感染;与病毒感染相比,细菌感染引起血小板降低更明显。
目的:探究血小闆減少與感染的關繫。方法迴顧性分析2010年6月~2011年6月我院收治的273例急、慢性感染相關性血小闆減少癥(非血液繫統疾病)的臨床資料。結果273例中男150例,女123例,平均年齡58.2(18~96)歲。血小闆計數(9~99)×109/L,平均(68.1±23.0)×109/L。引起血小闆減少癥的感染相關的病因分佈:消化繫統佔40.3%(110例),呼吸繫統33.7%(92例),泌尿繫統6.6%(18例),神經繫統2.9%(8例),皮膚2.6%(7例),五官1.8%(5例),心血管繫統1.5%(4例),其他繫統3.7%(10例),多繫統7.0%(19例)。有明確病原學證據的感染196例(71.8%),包括病毒佔28.2%(77例),細菌28.2%(77例),真菌15.4%(42例);未能明確病原體的感染28.2%(77例)。疾病伴隨癥狀和輔助檢查:髮熱27.1%(74例),血培養暘性8.4%(23例),痰培養暘性25.3%(69例),中性粒細胞增多24.5%(67)。細菌感染引起的血小闆減少最低值較病毒感染低,差異有統計學意義(P<0.05);細菌與真菌、病毒與真菌感染引起血小闆減少最低值無顯著差異。結論感染相關性血小闆減少癥中以病毒、細菌感染最常見,其次為真菌感染;與病毒感染相比,細菌感染引起血小闆降低更明顯。
목적:탐구혈소판감소여감염적관계。방법회고성분석2010년6월~2011년6월아원수치적273례급、만성감염상관성혈소판감소증(비혈액계통질병)적림상자료。결과273례중남150례,녀123례,평균년령58.2(18~96)세。혈소판계수(9~99)×109/L,평균(68.1±23.0)×109/L。인기혈소판감소증적감염상관적병인분포:소화계통점40.3%(110례),호흡계통33.7%(92례),비뇨계통6.6%(18례),신경계통2.9%(8례),피부2.6%(7례),오관1.8%(5례),심혈관계통1.5%(4례),기타계통3.7%(10례),다계통7.0%(19례)。유명학병원학증거적감염196례(71.8%),포괄병독점28.2%(77례),세균28.2%(77례),진균15.4%(42례);미능명학병원체적감염28.2%(77례)。질병반수증상화보조검사:발열27.1%(74례),혈배양양성8.4%(23례),담배양양성25.3%(69례),중성립세포증다24.5%(67)。세균감염인기적혈소판감소최저치교병독감염저,차이유통계학의의(P<0.05);세균여진균、병독여진균감염인기혈소판감소최저치무현저차이。결론감염상관성혈소판감소증중이병독、세균감염최상견,기차위진균감염;여병독감염상비,세균감염인기혈소판강저경명현。
Objective To investigate the cause and disease distribution of thromosytopenia in infected patients.Methods A retrospective analysis was conducted in 273 patients with acute and chronic infection-associated thrombosytopenia from June 2010 to June 2011.Results A total of 273 patients(150 men and 123 women,mean age 58.2 years,range from 18 ~96 years) were studied.The causes of infection-associated thrombosytopenia were distributed over digestive system (40.3%,110/273),respiratory system(33.7%,92/273),multisystem(7.0%,19/273),urinary system(6.6%,18/273),other system(3.7%,10/273),nervous system(2.9%,8/273),dermal system(2.6%,7/273),facial features system(1.8%,5/273)and cardiovas-cular system ( 1 .5%, 4/273 ) .Pathogens detected positively ( 71 .8%, 196/273 ) were constitutive of virus (28.2%,77/273),bacterium(28.2%,77/273),fungus(15.4%,42/273)whereas pathogens detected nega-tively were 28 .2%( 77/273 ) .The main symptom and laboratory examination were fever ( 27 .1%,74/273 ) , blood culture positive(7.7%,21/273),sputum positive(24.9%,68/273)and increased total-WBC number (24.5%,67/273).The mean platelet count of 273 patients was(68.1 ±23.0) ×109/L,ranging from 9~99 ×109/L.The minimum value of thrombocytopenia caused by bacterium was significantly lower compared with virus(P<0.05).There were no significantly different about the minimum value of thrombocytopenia caused by virus compared with fungus and bacterium compared with fungus .Conclusion Among the pathogens which lead to thrombocytopenia , virus and bacterium occupy first and second place and fungus comes third . The value of thrombocytopenia caused by bacterium was significantly lower compared with virus .Compared with fungus ,no significantly different value of thrombocytopenia caused by virus and bacterium .