CAJ | 학술논문

目的：探讨静脉用丙种球蛋白(IVIG)治疗慢性阻塞性肺疾病(COPD)合并真菌感染的临床价值。方法72例临床诊断为COPD合并真菌感染的患者入选,被随机分为常规组和干预组,每组36例。常规组给予抗感染、平喘及抗真菌药物治疗；干预组在上述治疗基础上,加用 IVIG,每日1次,每次10 g。根据患者的临床症状改善情况,进行疗效评价,记录患者住院时间及预后。结果干预组的治疗有效率为88.89%(32/36),明显高于常规组的66.67%(24/36)；平均住院时间为(12.62±7.51)d,明显短于常规组的(20.81±6.92)d；病死率为5.56%(2/36),低于常规组的22.22%(8/36),差异均有统计学意义(均P<0.05)。结论 IVIG治疗 COPD合并真菌感染可提高临床疗效,缩短患者住院时间,降低病死率。
목적：탐토정맥용병충구단백(IVIG)치료만성조새성폐질병(COPD)합병진균감염적림상개치。방법72례림상진단위COPD합병진균감염적환자입선,피수궤분위상규조화간예조,매조36례。상규조급여항감염、평천급항진균약물치료；간예조재상술치료기출상,가용 IVIG,매일1차,매차10 g。근거환자적림상증상개선정황,진행료효평개,기록환자주원시간급예후。결과간예조적치료유효솔위88.89%(32/36),명현고우상규조적66.67%(24/36)；평균주원시간위(12.62±7.51)d,명현단우상규조적(20.81±6.92)d；병사솔위5.56%(2/36),저우상규조적22.22%(8/36),차이균유통계학의의(균P<0.05)。결론 IVIG치료 COPD합병진균감염가제고림상료효,축단환자주원시간,강저병사솔。
Objective To explore the clinical effect of intravenous immunoglobulin(IVIG)on chronic obstructive pulmonary disease(COPD)and fungal infection.Methods Seventy-two COPD patients with fungal infection were randomly and equally divided into conventional and intervention group.Patients in conventional group were treated with common schedule for COPD plus antifungal agents;patients in intervention group received 1 0 g/d IVIG besides routine therapy.Length of hospital stay and prognosis were recorded,and therapeutic effectiveness were evaluated. Results The effectiveness rate of intervention group was significantly higher than that of conventional group ([88.89%,32/36]vs [66.67%,24/36]);the average length of hospital stay was significantly shorter than conven-tional group ([12.62±7.51]d vs [20.81±6.92]d),and mortality was lower than conventional group ([5.56%, 2/36]vs [22.22%,8/36]),the differences were statistically significant (P<0.05).Conclusion IVIG for treating COPD with invasive pulmonary fungal infection can improve therapeutic efficacy,shorten length of hospital stay and decrease mortality rate.