中国实验诊断学
中國實驗診斷學
중국실험진단학
CHINESE JOURNAL OF LABORATORY DIAGNOSIS
2014年
6期
990-992
,共3页
类风湿因子%抗环瓜氨酸肽抗体%类风湿关节炎
類風濕因子%抗環瓜氨痠肽抗體%類風濕關節炎
류풍습인자%항배과안산태항체%류풍습관절염
Rheumatoid factor%Anti-cyclic citrullinated peptide antibody%Rheumatoid arthritis
目的:探讨类风湿因子(RF)与抗环瓜氨酸肽抗体(抗-CCP 抗体)联合检测对类风湿关节炎(RA)的诊断价值。方法回顾分析87例 RA、34例系统性红斑狼疮(SLE)、29例混合性结缔组织病(MCTD)、21例干燥综合征(SS)患者的 RF、抗-CCP 抗体检测结果,RF 测定采用免疫比浊法,抗-CCP 抗体测定采用酶联免疫吸附试验(ELISA)。结果①RA 组患者的 RF 和抗-CCP 抗体检测结果均高于其他三组患者,差异均有统计学意义(P <0.05)。②RF 诊断 RA 的灵敏度、特异度、阳性预测值、阴性预测值、诊断准确度分别为86.2%、72.6%、76.5%、83.6%、79.5%。③抗-CCP 抗体诊断 RA 的灵敏度、特异度、PPV、NPV、诊断准确度分别为81.6%、85.7%、85.5%、81.8%、83.6%。④采用序列试验联合检测 RF、抗-CCP 抗体,此时诊断 RA 的灵敏度、特异度、PPV、NPV、诊断准确度分别为79.3%、94.0%、93.2%、81.4%、86.5%。结论采用序列试验联合检测 RF、抗-CCP 抗体可以提高 RA 的诊断特异度,有利于 RA 与其他自身免疫性疾病的鉴别诊断。
目的:探討類風濕因子(RF)與抗環瓜氨痠肽抗體(抗-CCP 抗體)聯閤檢測對類風濕關節炎(RA)的診斷價值。方法迴顧分析87例 RA、34例繫統性紅斑狼瘡(SLE)、29例混閤性結締組織病(MCTD)、21例榦燥綜閤徵(SS)患者的 RF、抗-CCP 抗體檢測結果,RF 測定採用免疫比濁法,抗-CCP 抗體測定採用酶聯免疫吸附試驗(ELISA)。結果①RA 組患者的 RF 和抗-CCP 抗體檢測結果均高于其他三組患者,差異均有統計學意義(P <0.05)。②RF 診斷 RA 的靈敏度、特異度、暘性預測值、陰性預測值、診斷準確度分彆為86.2%、72.6%、76.5%、83.6%、79.5%。③抗-CCP 抗體診斷 RA 的靈敏度、特異度、PPV、NPV、診斷準確度分彆為81.6%、85.7%、85.5%、81.8%、83.6%。④採用序列試驗聯閤檢測 RF、抗-CCP 抗體,此時診斷 RA 的靈敏度、特異度、PPV、NPV、診斷準確度分彆為79.3%、94.0%、93.2%、81.4%、86.5%。結論採用序列試驗聯閤檢測 RF、抗-CCP 抗體可以提高 RA 的診斷特異度,有利于 RA 與其他自身免疫性疾病的鑒彆診斷。
목적:탐토류풍습인자(RF)여항배과안산태항체(항-CCP 항체)연합검측대류풍습관절염(RA)적진단개치。방법회고분석87례 RA、34례계통성홍반랑창(SLE)、29례혼합성결체조직병(MCTD)、21례간조종합정(SS)환자적 RF、항-CCP 항체검측결과,RF 측정채용면역비탁법,항-CCP 항체측정채용매련면역흡부시험(ELISA)。결과①RA 조환자적 RF 화항-CCP 항체검측결과균고우기타삼조환자,차이균유통계학의의(P <0.05)。②RF 진단 RA 적령민도、특이도、양성예측치、음성예측치、진단준학도분별위86.2%、72.6%、76.5%、83.6%、79.5%。③항-CCP 항체진단 RA 적령민도、특이도、PPV、NPV、진단준학도분별위81.6%、85.7%、85.5%、81.8%、83.6%。④채용서렬시험연합검측 RF、항-CCP 항체,차시진단 RA 적령민도、특이도、PPV、NPV、진단준학도분별위79.3%、94.0%、93.2%、81.4%、86.5%。결론채용서렬시험연합검측 RF、항-CCP 항체가이제고 RA 적진단특이도,유리우 RA 여기타자신면역성질병적감별진단。
Objective To investigate the clinical value of rheumatoid factor(RF)and anti-cyclic citrullinated peptide antibody(anti-CCP antibody)in the diagnosis of rheumatoid arthritis(RA).Methods The RF and anti-CCP antibody results of 87 cases of RA,34 cases of systemic lupus erythematosus(SLE),29 cases of mixed connective tissue disease (MCTD),21 cases of Sjogren's syndrome(SS)were analyzed retrospectively,and the RF was measured by immunotur-bidimetry,while the anti-CCP antibody was by enzyme linked immunosorbent assay(ELISA).Results ①RF and anti-CCP antibody test results RA patients were higher than the other three groups of patients,the differences were statisti-cally significant(P <0.05).②For diagnosis of RA,the RF had a sensitivity of 86.2%,specificity of 72.6%,positive <br> predictive value(PPV)of 76.5%,negative predictive value(NPV)of 83.6%,and overall accuracy of 79.5%.③For di-agnosis of RA,the anti-CCP antibody had a sensitivity of 81.6%,specificity of 85.7%,PPV of 85.5%,NPV of 81.8%,and overall accuracy of 83.6% in the diagnosis of RA.④The RF and anti-CCP antibody by serial method had a sensitivity of 79.3%,specificity of 94.0%,PPV of 93.2%,NPV of 81.4%,and overall accuracy of 86.5% in the diag-nosis of RA.Conclusion The RF and anti-CCP antibody by serial method is able to improve the specificity in the diag-nosis of RA,so this way contributes to differential diagnosis of RA and other autoimmune diseases.