CAJ | 학술논문

目的：观察糖尿病慢性并发症患者血浆血栓调节蛋白（TM），蛋白 C（PC），蛋白 S（PS），抗凝血酶（AT-Ⅲ）的变化，了解这些因子在糖尿病慢性并发症凝血功能变化中的意义。方法按糖尿病常见并发症分为4组：糖尿病无并发症20例，糖尿病肾病（DN）20例，糖尿病视网膜病变（DR）20例，糖尿病足（DF）20例，以及年龄相匹配的健康正常人20例作为对照组，分别应 ELISA 方法测定血浆 TM 浓度，日本 sysmex 6000全自动凝血分析仪测定 PC，PS，AT-Ⅲ浓度。结果各血浆 TM，PC，PS 水平均明显高于正常对照组（P ＜0．05），AT-Ⅲ水平低于正常对照组（P ＜0．05）；并发症组血浆 TM，PC，PS 水平均高于无并发症组（P ＜0．05），而 AT-Ⅲ活性低于无并发症组（P ＜0．05），在有并发症组之间无显著变化（P ＞0．05）。结论糖尿病患者血浆 TM，PC，PS 及 AT-Ⅲ的浓度变化对 DN，DR 和 DF 的早期诊断和病情分析有重要的临床价值。
목적：관찰당뇨병만성병발증환자혈장혈전조절단백（TM），단백 C（PC），단백 S（PS），항응혈매（AT-Ⅲ）적변화，료해저사인자재당뇨병만성병발증응혈공능변화중적의의。방법안당뇨병상견병발증분위4조：당뇨병무병발증20례，당뇨병신병（DN）20례，당뇨병시망막병변（DR）20례，당뇨병족（DF）20례，이급년령상필배적건강정상인20례작위대조조，분별응 ELISA 방법측정혈장 TM 농도，일본 sysmex 6000전자동응혈분석의측정 PC，PS，AT-Ⅲ농도。결과각혈장 TM，PC，PS 수평균명현고우정상대조조（P ＜0．05），AT-Ⅲ수평저우정상대조조（P ＜0．05）；병발증조혈장 TM，PC，PS 수평균고우무병발증조（P ＜0．05），이 AT-Ⅲ활성저우무병발증조（P ＜0．05），재유병발증조지간무현저변화（P ＞0．05）。결론당뇨병환자혈장 TM，PC，PS 급 AT-Ⅲ적농도변화대 DN，DR 화 DF 적조기진단화병정분석유중요적림상개치。
Objective In order to understand the significance of these factors in variation of coagulation of diabetic chronic complications,we observe the variation of plasma thromboxane regulating protein (TM),protein C (PC),pro-tein S (PS),antithrombin (AT-Ⅲ)in patients with chronic complications of diabetes.Methods The common complica-tion of diabetes were divided into 4 groups:diabetes without complications(20 cases),diabetic nephropathy (DN)(20 cases),diabetic retinopathy lesions (DR)(20 cases),diabetic foot (DF)(20 cases),as well as the normal healthy peo-ple with corresponding age(20 cases)as control groups,and the blood plasma TM concentration should be determined by ELISA,PC,PS,AT-Ⅲ concentration should be tested by Japan Sysmex 6000 fully automatic blood coagulation ana-lyzer respectively.Results The level of TM,PC and PS in blood plasma were significantly higher than control group (P<0.05),AT-Ⅲ levels lower than the normal control group (P <0.05);the average level of TM,PC and PS of blood plasma in patients with complications was obviously higher than those patients without complications(P <0.05),how-ever,AT-Ⅲ activity of blood plasma in patients with complications was somehow lower than those patients without complications(P <0.05),which turned out to be original standard (P >0.05).Conclusion The variations of TM,PC, PS and AT-Ⅲ concentration in blood plasma to diabetic patient are clinically important for the early diagnosis and dis-ease analysis of DN,DR,and DF.