CAJ | 학술논문

目的：探讨广州地区过敏性紫癜患儿变应原组成情况，为临床寻找诱因及预防提供依据。方法采用德国敏筛变应原检测系统，检测广州地区161例过敏性紫癜患儿血清变应原特异性 IgE 和总 IgE 含量，并将患儿分成＜7岁组（幼儿期及学龄前期）和≥7岁组（学龄期及青春期），回顾性分析本地区不同年龄组过敏性紫癜患儿最常见的血清变应原特异性 IgE 阳性率及其分布差异。结果过敏性紫癜患儿变应原特异性 IgE 阳性60例（37．27％），其中吸入变应原特异性 IgE 阳性率最高为屋尘螨（23．6％）和屋尘（14．91％）；食入变应原特异性 IgE 阳性率最高为牛奶（6．83％）和鸡蛋白鸡蛋黄（6．21％）。吸入变应原特异性 IgE 阳性率高于食入变应原（P ＜0．05）。血清总 IgE 阳性67例（41．6％）。＜7岁组患儿牛奶的阳性率高于年长儿（P ＜0．05）。结论广州地区过敏性紫癜患儿最主要变应原是屋尘螨、屋尘、牛奶、鸡蛋白鸡蛋黄，可为本地区参考。吸入变应原特异性 IgE 检出率高于食入变应原。＜7岁（幼儿期及学龄前期）的过敏性紫癜患儿对牛奶过敏的比例高于≥7岁（学龄期及青春期）的年长儿。
목적：탐토엄주지구과민성자전환인변응원조성정황，위림상심조유인급예방제공의거。방법채용덕국민사변응원검측계통，검측엄주지구161례과민성자전환인혈청변응원특이성 IgE 화총 IgE 함량，병장환인분성＜7세조（유인기급학령전기）화≥7세조（학령기급청춘기），회고성분석본지구불동년령조과민성자전환인최상견적혈청변응원특이성 IgE 양성솔급기분포차이。결과과민성자전환인변응원특이성 IgE 양성60례（37．27％），기중흡입변응원특이성 IgE 양성솔최고위옥진만（23．6％）화옥진（14．91％）；식입변응원특이성 IgE 양성솔최고위우내（6．83％）화계단백계단황（6．21％）。흡입변응원특이성 IgE 양성솔고우식입변응원（P ＜0．05）。혈청총 IgE 양성67례（41．6％）。＜7세조환인우내적양성솔고우년장인（P ＜0．05）。결론엄주지구과민성자전환인최주요변응원시옥진만、옥진、우내、계단백계단황，가위본지구삼고。흡입변응원특이성 IgE 검출솔고우식입변응원。＜7세（유인기급학령전기）적과민성자전환인대우내과민적비례고우≥7세（학령기급청춘기）적년장인。
Objective To study the relationship between allergens and the causes in children with Henoch-Schonlein purpura in Guangzhou.Methods Using the German screen allergens quantitative detection system to determinate ser-um allergen-specific IgE and total IgE levels of 161 cases in children with Henoch-Schonlein purpura.The samples were stratified on two age groups:<7 years old group (infancy and preschool)and ≥ 7 years old group (school-age and ado-lescent).Difference of serum allergen-specific IgE of the two groups were investigated.Results 37.27% (60/161) children with Henoch-Schonlein purpura showed specific IgE positive.Total IgE in serum was positive in 67 cases,ac-counting for 41.6%.Mite mixture (23.6%)and house dust(14.91%)were the main aeroallergens while milk(6.83%) and egg(6.21%)were the main ingestive allergens.The positive rate of aeroallergen specific IgE was higher than ingest-ive allergens(P <0.05).There was higher positive rate of milk in the <7 years old group (infancy and preschool)than≥ 7 years old group (school-age and adolescent)(P <0.05).Conclusion The mainly allergens of Henoch-Schonlein purpura were mite mixture,house dust,milk,egg,which could be referenced as Guangzhou patients.The younger child (<7 years old)is more sensitive to milk than the older(≥ 7 years old).