CAJ | 학술논문

目的：探讨氯雷他定治疗儿童喘息性支气管炎的临床疗效及对体液免疫的影响。方法将本院诊治的112例喘息性支气管炎患儿随机分为对照组与观察组,两组均给予常规治疗,观察组同时接受氯雷他定5 mg/d,口服,疗程2周。比较两组临床疗效、治疗前后体液免疫及T细胞亚群的变化。结果两组治疗后临床症状明显改善；观察组的临床疗效及免疫指标明显优于对照组( P<0．05)。结论喘息性支气管炎患儿机体存在体液免疫低下和T细胞亚群紊乱,氯雷他定可提高机体免疫功能,有利于改善临床症状及减少复发。
목적：탐토록뢰타정치료인동천식성지기관염적림상료효급대체액면역적영향。방법장본원진치적112례천식성지기관염환인수궤분위대조조여관찰조,량조균급여상규치료,관찰조동시접수록뢰타정5 mg/d,구복,료정2주。비교량조림상료효、치료전후체액면역급T세포아군적변화。결과량조치료후림상증상명현개선；관찰조적림상료효급면역지표명현우우대조조( P<0．05)。결론천식성지기관염환인궤체존재체액면역저하화T세포아군문란,록뢰타정가제고궤체면역공능,유리우개선림상증상급감소복발。
Objective To explore the effect of loratadine on humoral immunity of children with asthmatic bronchitis. Methods 112 children with asthmatic bronchitis were randomly divided into control group and treatment group. All the subjects received routine treatment. Treatment group was given oral loratadine 5 mg/d for 2 weeks. The clinical effects and humoral immunity and T lymphocyte subsets before and after treatment between the two groups were compared. Results The clinical symptoms of the two groups obviously improved after treatment. The efficacy and immunology indicators of treatment group was obviously superior to those of control group after treatment ( P <0. 05 ) . Conclusion Children with asthmatic bronchitis has depression of humoral immunity and disorder of T lympho-cyte subsets. Loratadine can improve the humoral immunity and it is benefit for improving clinlcal symptom.