CAJ | 학술논문

目的：对比评价马来酸噻吗洛尔与布林佐胺联合曲伏前列素治疗开角型青光眼和高眼压症的临床疗效。方法将我院使用曲伏前列素单药治疗效果不佳的开角型青光眼与高眼压的76例患者分为S组和B组,S组38例(38眼)患者在曲伏前列素基础上合用马来酸噻吗洛尔治疗,B组38例(38眼)患者则合用布林佐胺治疗,于2周和1、3、6个月随访。对比观察两组治疗前后的平均眼压、昼夜眼压差、心率、血压和不良反应发生情况。结果两组患者在联合用药后2周和1、3、6个月平均眼压下降,与治疗前比较差异均有统计学意义(P<0．05),两组间差异无统计学意义(P>0．05)；S组联合用药后6个月昼夜眼压差较B组大,两组差异有统计学意义(P<0．05)；两组患者在联合用药前后血压均无明显变化(P>0．05)；B组患者心率在联合用药前后无明显变化(P>0．05),S组患者心率则在随访6个月时出现明显心脏抑制(P<0．05)；两组均未出现严重不良反应。结论马来酸噻吗洛尔与布林佐胺联合曲伏前列素治疗开角型青光眼和高眼压疗效显著,布林佐胺联合曲伏前列素用药相对更稳定、更安全。
목적：대비평개마래산새마락이여포림좌알연합곡복전렬소치료개각형청광안화고안압증적림상료효。방법장아원사용곡복전렬소단약치료효과불가적개각형청광안여고안압적76례환자분위S조화B조,S조38례(38안)환자재곡복전렬소기출상합용마래산새마락이치료,B조38례(38안)환자칙합용포림좌알치료,우2주화1、3、6개월수방。대비관찰량조치료전후적평균안압、주야안압차、심솔、혈압화불량반응발생정황。결과량조환자재연합용약후2주화1、3、6개월평균안압하강,여치료전비교차이균유통계학의의(P<0．05),량조간차이무통계학의의(P>0．05)；S조연합용약후6개월주야안압차교B조대,량조차이유통계학의의(P<0．05)；량조환자재연합용약전후혈압균무명현변화(P>0．05)；B조환자심솔재연합용약전후무명현변화(P>0．05),S조환자심솔칙재수방6개월시출현명현심장억제(P<0．05)；량조균미출현엄중불량반응。결론마래산새마락이여포림좌알연합곡복전렬소치료개각형청광안화고안압료효현저,포림좌알연합곡복전렬소용약상대경은정、경안전。
Objective To evaluate the clinical efficacy of timolol maleate and brinzolamide in treatment of open-angle glaucoma and ocular hypertension combined with travoprost. Methods 76 patients were divided into group S and group B in our hospital,who were suffering from open-angle glaucoma or ocular hypertension,and the clinical ef-ficacy was poor when they were treated with travoprost monotherapy. 38 patients(38 eyes) in group S were treated with timolol maleate,and 38 patients(38 eyes) in group B were treated with brinzolamide,combined with travoprost. Fol-low-up was scheduled after 2 weeks,1,3 and 6 months of combination therapy. The mean IOP (meanIntraocular pres-sure),diurnal IOP difference,heart rate,blood pressure and the incidence of adverse reactions were compared before and after combination therapy. Results The mean IOP decreased after two weeks and 1,3,6 month of combination therapy in 2 groups had significant difference compared with before combination therapy(P<0. 05),and it was no sig-nificant difference between the two groups(P>0. 05). The difference of diurnal IOP was significant between the two groups after 6 months of combination therapy(P<0. 05),and the group S was higher than group B. The blood pressure did not change significantly before and after combination therapy in 2 groups(P>0. 05). The heart rate did not change significantly,and the patients of group S showed significant cardiac depression after 6 months follow-up (P<0. 05). No serious adverse events occurred in both groups. Conclusion The clinical efficacy would significant when it is trea-ted for open-angle glaucoma and ocular hypertension,either timolol maleate or brinzolamide combined travopros,and the clinical efficacy would be stable and safe when brinzolamide is applied than timolol maleate.