CAJ | 학술논문

目的：探讨乌司他丁对脓毒血症患者免疫功能的影响。方法将106例脓毒血症患者随机分为对照组和观察组,每组53例。两组患者均接受常规治疗,观察组患者同时给予乌司他丁。于治疗前后抽取患者外周静脉血,检测其淋巴细胞亚群和TNF-α、IL-10并进行分析。结果治疗前,两组患者血清CD3+、CD4+、CD8+水平,CD4+/CD8+比值以及TNF-α和IL-10水平比较差异无统计学意义(P>0．05)。治疗后,观察组患者CD3+、CD4+水平及CD4+/CD8+比值明显优于对照组患者( P<0．05),但两组患者CD8+水平比较差异无统计学意义(P>0．05)；治疗后,观察组 TNF-α及 IL-10水平明显低于对照组,两组比较差异有统计学意义(P <0．05)。结论乌司他丁可有效改善脓毒血症患者的免疫功能。
목적：탐토오사타정대농독혈증환자면역공능적영향。방법장106례농독혈증환자수궤분위대조조화관찰조,매조53례。량조환자균접수상규치료,관찰조환자동시급여오사타정。우치료전후추취환자외주정맥혈,검측기림파세포아군화TNF-α、IL-10병진행분석。결과치료전,량조환자혈청CD3+、CD4+、CD8+수평,CD4+/CD8+비치이급TNF-α화IL-10수평비교차이무통계학의의(P>0．05)。치료후,관찰조환자CD3+、CD4+수평급CD4+/CD8+비치명현우우대조조환자( P<0．05),단량조환자CD8+수평비교차이무통계학의의(P>0．05)；치료후,관찰조 TNF-α급 IL-10수평명현저우대조조,량조비교차이유통계학의의(P <0．05)。결론오사타정가유효개선농독혈증환자적면역공능。
Objective To investigate the effects of ulinastatin on immune function in patients with sepsis. Methods 106 cases of sepsis patients were randomly divided into control group and observation group,53 cases in each group. All patients received conventional treatment,and observe group was given ulinastatin at the same time. Be-fore and after treatment,the peripheral blood of all patients was extracted to detect lymphocyte subsets and TNF-α,IL-10. Results Before treatment,the levels of CD3 +,CD4 +,CD8 +,CD4 + /CD8 + ratio,TNF-α and IL-10 of the two groups had no significant difference (P>0. 05). After treatment,the levels of CD3 +,CD4 + and CD4 + /CD8 + ratio of the observation group were significantly improved,better than those of the control group (P<0. 05). While the CD8 +levels of the two groups had no significant difference (P>0. 05). After treatment,the levels of TNF-αand IL-10 of the observation group were significantly lower than those of the control group,the difference had significant difference( P<0. 05). Conclusion Ulinastatin can improve immune function in patients with sepsis.