实用药物与临床
實用藥物與臨床
실용약물여림상
PRACTICAL PHARMACY AND CLINICAL REMEDIES
2014年
6期
711-714
,共4页
蔡军波%张强%方芳%杨林军
蔡軍波%張彊%方芳%楊林軍
채군파%장강%방방%양림군
优甲乐%小金胶囊%结节性甲状腺肿%安全性
優甲樂%小金膠囊%結節性甲狀腺腫%安全性
우갑악%소금효낭%결절성갑상선종%안전성
Euthyrox%Xiaojin capsule%Nodular goiter%Safety
目的:探讨小剂量优甲乐联合小金胶囊治疗结节性甲状腺肿的临床疗效以及安全性。方法选择我科收治的结节性甲状腺肿患者64例,随机分为观察组和对照组,对照组给予优甲乐治疗,观察组给予优甲乐联合小金胶囊治疗,同时减少优甲乐剂量。治疗3个月后,对比分析两组的临床疗效,治疗前后甲状腺功能相关指标变化以及不良反应发生情况。结果治疗3个月后,观察组总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后最大结节直径较治疗前明显缩短,差异均有统计学意义(P<0.01),观察组治疗后最大结节改善程度优于对照组,差异有统计学意义( P<0.01)。观察组sTSH水平较治疗前有所降低,但差异无统计学意义(P>0.05),对照组sTSH水平较治疗前明显降低,差异有统计学意义(P<0.01)。观察组治疗后sTSH水平降低幅度明显小于对照组,差异有统计学意义(P<0.01)。观察组不良反应发生率为6.3%,对照组为34.4%,两组比较差异有统计学意义(P<0.01)。结论小剂量优甲乐联合小金胶囊治疗结节性甲状腺肿,临床疗效良好,对甲状腺功能影响较小,且明显降低了优甲乐所致不良反应的发生率。
目的:探討小劑量優甲樂聯閤小金膠囊治療結節性甲狀腺腫的臨床療效以及安全性。方法選擇我科收治的結節性甲狀腺腫患者64例,隨機分為觀察組和對照組,對照組給予優甲樂治療,觀察組給予優甲樂聯閤小金膠囊治療,同時減少優甲樂劑量。治療3箇月後,對比分析兩組的臨床療效,治療前後甲狀腺功能相關指標變化以及不良反應髮生情況。結果治療3箇月後,觀察組總有效率明顯高于對照組,差異有統計學意義(P<0.05)。兩組治療後最大結節直徑較治療前明顯縮短,差異均有統計學意義(P<0.01),觀察組治療後最大結節改善程度優于對照組,差異有統計學意義( P<0.01)。觀察組sTSH水平較治療前有所降低,但差異無統計學意義(P>0.05),對照組sTSH水平較治療前明顯降低,差異有統計學意義(P<0.01)。觀察組治療後sTSH水平降低幅度明顯小于對照組,差異有統計學意義(P<0.01)。觀察組不良反應髮生率為6.3%,對照組為34.4%,兩組比較差異有統計學意義(P<0.01)。結論小劑量優甲樂聯閤小金膠囊治療結節性甲狀腺腫,臨床療效良好,對甲狀腺功能影響較小,且明顯降低瞭優甲樂所緻不良反應的髮生率。
목적:탐토소제량우갑악연합소금효낭치료결절성갑상선종적림상료효이급안전성。방법선택아과수치적결절성갑상선종환자64례,수궤분위관찰조화대조조,대조조급여우갑악치료,관찰조급여우갑악연합소금효낭치료,동시감소우갑악제량。치료3개월후,대비분석량조적림상료효,치료전후갑상선공능상관지표변화이급불량반응발생정황。결과치료3개월후,관찰조총유효솔명현고우대조조,차이유통계학의의(P<0.05)。량조치료후최대결절직경교치료전명현축단,차이균유통계학의의(P<0.01),관찰조치료후최대결절개선정도우우대조조,차이유통계학의의( P<0.01)。관찰조sTSH수평교치료전유소강저,단차이무통계학의의(P>0.05),대조조sTSH수평교치료전명현강저,차이유통계학의의(P<0.01)。관찰조치료후sTSH수평강저폭도명현소우대조조,차이유통계학의의(P<0.01)。관찰조불량반응발생솔위6.3%,대조조위34.4%,량조비교차이유통계학의의(P<0.01)。결론소제량우갑악연합소금효낭치료결절성갑상선종,림상료효량호,대갑상선공능영향교소,차명현강저료우갑악소치불량반응적발생솔。
Objective To investigate the clinical curative effect of small doses of euthyrox combined with Xi-aojin capsule on nodular goiter and the safety. Methods 64 cases of nodular goiter patients were randomly divided into observation group and control group, the control group was treated with euthyrox, the observation group was treated with small doses of euthyrox combined with Xiaojin capsule. After 3 months treatment,the clinical curative effect,relat-ed parameters of thyroid function changes and the adverse reaction of the two groups were compared. Results After 3 months treatment,the total effective rate of the observation group was significantly higher than that of control group (P<0. 05). The largest nodule diameter of the two groups significantly reduced than before treatment (P<0. 01),the improved degree of the largest nodule diameter of observation group was better than that of the control group ( P <0. 01). sTSH level of the observation group reduced than before treatment,but there was no significant difference (P>0. 05 ) ,sTSH level of control group significantly reduced than before treatment,the difference had statistical significance (P<0. 01). After treatment,the sTSH level of observation group was significantly less than that of control group (P<0. 01). The adverse reaction rate of observation group was 6. 3%,while it was 34. 4% of the control group,the differ-ence had significant difference (P<0. 01). Conclusion Nodular goiter treated with small doses of euthyrox combined with Xiaojin capsule not only can obtain better clinical curative effect,but also has less effect on thyroid function,and significantly reduce the incidence of adverse reaction.