CAJ | 학술논문

目的：探讨卡维地洛联合曲美他嗪对缺血性心肌病心衰患者左室功能及QT间期离散度的影响。方法将我院诊治的80例缺血性心肌病心衰患者随机分入对照组与治疗组，对照组患者接受卡维地洛口服，治疗组患者接受卡维地洛联合曲美他嗪口服，疗程6个月。比较两组左室功能、血压、心率及QT间期离散度的改变。结果治疗6个月后，治疗组左室舒张末期内径( LVEDd )、左室射血分数( LVEF )、室间隔厚度(IVSD)、左室重量指数(LVMI)及左室后壁(PWTD)显著优于对照组(P<0．05)；与对照组相比，治疗组QT间期离散度(QTd)及心率校正 QT 间期(QTcd)显著下降(P <0．05)；两组治疗后心率、收缩压(SBP)及舒张压(DBP)差异无统计学意义(P>0．05)。结论卡维地洛联合曲美他嗪治疗缺血性心肌病心衰可显著改善患者左室功能，缩短QTd及QTcd。
목적：탐토잡유지락연합곡미타진대결혈성심기병심쇠환자좌실공능급QT간기리산도적영향。방법장아원진치적80례결혈성심기병심쇠환자수궤분입대조조여치료조，대조조환자접수잡유지락구복，치료조환자접수잡유지락연합곡미타진구복，료정6개월。비교량조좌실공능、혈압、심솔급QT간기리산도적개변。결과치료6개월후，치료조좌실서장말기내경( LVEDd )、좌실사혈분수( LVEF )、실간격후도(IVSD)、좌실중량지수(LVMI)급좌실후벽(PWTD)현저우우대조조(P<0．05)；여대조조상비，치료조QT간기리산도(QTd)급심솔교정 QT 간기(QTcd)현저하강(P <0．05)；량조치료후심솔、수축압(SBP)급서장압(DBP)차이무통계학의의(P>0．05)。결론잡유지락연합곡미타진치료결혈성심기병심쇠가현저개선환자좌실공능，축단QTd급QTcd。
Objective To explore the effect of carvedilol combined with trimetazidine on left ventricular func-tion and QTd in patients with ischemic cardiomyopathy complicated with heart failure. Methods 80 patients with is-chemic cardiomyopathy complicated with heart failure were randomly divided into control group and treatment group. Control group received carvedilol treatment and treatment group was given carvedilol combined with trimetazidine. The course of treatment was 6 months. Left ventricular function,blood pressure,heart rate and QTd were compared between the two groups. Results After 6 months′treatment,LVEDd,LVEF,IVSD,LVMI and PWTD of treatment group were superior to those of control group (P<0. 05);Compared with control group,QTd and QTcd of treatment group greatly decreased (P<0. 05). There were no significant difference of heart failure,SBP and DBP between the two groups (P>0. 05 ) . Conclusion Carvedilol combined with trimetazidine for ischemic cardiomyopathy complicated with heart failure can greatly improve the left ventricular function and induce QTd.