CAJ | 학술논문

目的：观察解毒化瘀方对肝硬化轻微型肝性脑病（ MHE）患者生存质量及中医证候的影响。方法80例肝硬化MHE患者，随机分为对照组、解毒化瘀方组，每组40例，2组均给予低蛋白饮食及复合维生素B治疗，其中解毒化瘀方组加用解毒化瘀颗粒，10g／包，冲服，2次／日，7天为1个疗程。分别观察治疗前、后数字连接试验-A（ NCT-A）、脑电图、WHO生存质量评定量表简表（ WHO QOL-BREF）及中医证候积分的变化。结果解毒化瘀方能显著缩短肝硬化MHE病患者NCT-A完成时间，提高患者生存质量，改善其脑电图及中医证候，且疗效优于对照组（P＜0.05）。结论解毒化瘀方具有改善肝硬化MHE患者生存质量及中医证候的作用。
목적：관찰해독화어방대간경화경미형간성뇌병（ MHE）환자생존질량급중의증후적영향。방법80례간경화MHE환자，수궤분위대조조、해독화어방조，매조40례，2조균급여저단백음식급복합유생소B치료，기중해독화어방조가용해독화어과립，10g／포，충복，2차／일，7천위1개료정。분별관찰치료전、후수자련접시험-A（ NCT-A）、뇌전도、WHO생존질량평정량표간표（ WHO QOL-BREF）급중의증후적분적변화。결과해독화어방능현저축단간경화MHE병환자NCT-A완성시간，제고환자생존질량，개선기뇌전도급중의증후，차료효우우대조조（P＜0.05）。결론해독화어방구유개선간경화MHE환자생존질량급중의증후적작용。
Objective To observe the curative effect of the detoxification and dissipation blood stasis formula on quality of life and syndrome of traditional Chinese medicine in hepatic cirrhosis with minimal hepatic encephalopathy ( MHE).Methods 80 cases hepatic cirrhosis MHE patients were randomly divided into controlled group , detoxification and dissipation blood stasis formula group .Each group had 40 cases.All groups were given low protein diet and the Vitamin B treatment , which detoxification and dissipation blood stasis formula group were treated with detoxification and dissipation blood stasis particles , 10g/package, p.o, bid.7 days were a course of treatment .At the beginning and the ending the number connection test-A ( NCT-A ) , electroencephalogram , WHO QOL-BREF and syndrome of traditional Chinese medicine were respectively examined and difference were found .Results Detoxification and dissipation blood stasis formula could significantly reduce the time of hepatic cirrhosis with MHE completing NCT-A, improve the quality of life , electroencephalogram and syndrome of Traditional Chinese medicine in cirrhosis patients with MHE .The curative effect rate was higher than the control group ( P<0.05).Conclusion The detoxification and dissipation blood stasis formula could improve quality of life and syndrome of traditional Chinese medicine in hepatic cirrhosis with minimal hepatic encephalopathy .