CAJ | 학술논문

胆管反应是指在肝祖细胞介导的肝脏修复过程中形成的局部细胞复合体.这种复合体包括有激活的肝祖细胞、中间型肝胆细胞和反应胆管细胞.胆管反应对肝癌发生发展具有重要作用.胆管反应中的肝干/祖细胞的恶性转化和迁移性是肝癌浸润和转移的基础,同时胆管反应又为肝癌的发生发展提供基质微环境.本文就胆管反应的分类、细胞多样性以及胆管反应在肝炎和肝癌发生发展中的作用研究进展进行综述,旨在研究胆管反应对阐明肝癌的发病机制,探索有效的治疗手段.
담관반응시지재간조세포개도적간장수복과정중형성적국부세포복합체.저충복합체포괄유격활적간조세포、중간형간담세포화반응담관세포.담관반응대간암발생발전구유중요작용.담관반응중적간간/조세포적악성전화화천이성시간암침윤화전이적기출,동시담관반응우위간암적발생발전제공기질미배경.본문취담관반응적분류、세포다양성이급담관반응재간염화간암발생발전중적작용연구진전진행종술,지재연구담관반응대천명간암적발병궤제,탐색유효적치료수단.
Ductular reaction (DR) is a phenomenon that refers to impaired hepatocellular proliferation and activated hepatic stem cells at times of demand such as hepatic regeneration.The components of ductular reactions are thought to be derived from activated hepatic progenitor cells,intermediate hepatobiliary cells,and reactive ductular cells.DRs are thought to play two roles in hepatocarcinogenesis:their hepatic progenitor cells may undergo malignant transformation and migration,and they may contribute to the development of the tumor's microenvironment.Exploring DR phenotype,cellular diversity,and relationship to hepatocarcinogenesis will further enhance our understanding of the pathogenesis of human hepatocellular carcinoma with an ultimate goal of developing new therapies.