CAJ | 학술논문

目的：评价低分子肝素在重症监护室长期卧床患者中应用的临床疗效。方法采用前瞻性研究方法，将46例长期卧床患者随机分组为低分子肝素组和对照组，两组均给予间歇压力充气泵下肢运动疗法，低分子肝素组另外给予低分子肝素钙抗凝。在此过程中收集并观察两组患者的临床资料，探讨低分子肝素对预防重症监护室长期卧床患者的深静脉血栓（DVT）发生率及肺栓塞发生的影响。结果低分子肝素组下肢深静脉血栓发生率、D-D 二聚体数值及氧合指数等方面与对照组比较差异均有统计学意义，而且两组患者在肺动脉高压发生率方面比较差异亦有统计学意义（P ﹤0.05），血小板及 PT 等影响出血指标两组比较差异无统计学意义。结论低分子肝素可显著降低重症监护室长期卧床患者的 DVT 发生率，进而可降低肺栓塞发生率，且安全有效。
목적：평개저분자간소재중증감호실장기와상환자중응용적림상료효。방법채용전첨성연구방법，장46례장기와상환자수궤분조위저분자간소조화대조조，량조균급여간헐압력충기빙하지운동요법，저분자간소조령외급여저분자간소개항응。재차과정중수집병관찰량조환자적림상자료，탐토저분자간소대예방중증감호실장기와상환자적심정맥혈전（DVT）발생솔급폐전새발생적영향。결과저분자간소조하지심정맥혈전발생솔、D-D 이취체수치급양합지수등방면여대조조비교차이균유통계학의의，이차량조환자재폐동맥고압발생솔방면비교차이역유통계학의의（P ﹤0.05），혈소판급 PT 등영향출혈지표량조비교차이무통계학의의。결론저분자간소가현저강저중증감호실장기와상환자적 DVT 발생솔，진이가강저폐전새발생솔，차안전유효。
Objective To evaluate the clinical effect of low molecular weight heparin on the long-term bedridden patients in ICU. Methods With a prospective study method,46 long-term bedridden patients were randomly divided into low molecular weight heparin group and control group,both groups were given intermittent pressure air pump motor therapy,low molecular weight heparin group were treated with low molecular weight hepa-rin anticoagulation. The clinical datas of the two groups were observed,the effect of low molecular weight heparin on the occurrence rate of DVT and pulmonary embolism in long-term bedridden patients were in-vestigate. Results The ultrasonic occurrence rate of deep vein thrombosis,D-D dimer numerical and oxygenation index were significantly different between the two groups,and the pulmonary arterial hyper-tension also showed significant differences between the two groups,at the same time,platelet and PT which affect the bleeding index showed no significant differences between the two groups. Conclusions Low molecular weight heparin can significantly reduce the incidence of DVT in ICU bedridden patients, which can reduce the incidence of pulmonary embolism,and is safe and effective.