CAJ | 학술논문

目的：观察呼出气一氧化氮（FeNO）在不同妊娠周期孕妇及妊娠哮喘患者中的变化，并探讨其在妊娠期哮喘患者中的诊治意义。方法收集健康妊娠女性46例（HP组），健康非妊娠女性30例（HNP组），哮喘非妊娠女性30例（ANP组），哮喘妊娠期女性26例（AP组）。比较各组及HP组中不同妊娠周期孕妇的FeNO水平；分析AP组患者FeNO水平与第1秒用力呼气量占预计值的百分比（FEV1%）、最大呼气流速峰值占预计值百分比（PEF%）的相关性。结果 AP组及ANP组FEV1%、PEF%均明显低于HNP组及HP组，FeNO水平均明显高于HNP组及HP组，差异均有统计学意义（均P＜0.05）；HNP组与HP组、AP组与ANP组FeNO水平、FEV1%及PEF%的差异均无统计学意义（均P＞0.05）。不同妊娠周期孕妇FeNO水平的差异均无统计学意义（均P＞0.05）。AP组患者FeNO水平与FEV1%及PEF%均无明显相关性（r=0.250、0.272，P＞0.05）。结论妊娠及妊娠周期对FeNO水平无明显影响， AP患者FeNO水平明显升高，FeNO水平与肺功能无明显相关。
목적：관찰호출기일양화담（FeNO）재불동임신주기잉부급임신효천환자중적변화，병탐토기재임신기효천환자중적진치의의。방법수집건강임신녀성46례（HP조），건강비임신녀성30례（HNP조），효천비임신녀성30례（ANP조），효천임신기녀성26례（AP조）。비교각조급HP조중불동임신주기잉부적FeNO수평；분석AP조환자FeNO수평여제1초용력호기량점예계치적백분비（FEV1%）、최대호기류속봉치점예계치백분비（PEF%）적상관성。결과 AP조급ANP조FEV1%、PEF%균명현저우HNP조급HP조，FeNO수평균명현고우HNP조급HP조，차이균유통계학의의（균P＜0.05）；HNP조여HP조、AP조여ANP조FeNO수평、FEV1%급PEF%적차이균무통계학의의（균P＞0.05）。불동임신주기잉부FeNO수평적차이균무통계학의의（균P＞0.05）。AP조환자FeNO수평여FEV1%급PEF%균무명현상관성（r=0.250、0.272，P＞0.05）。결론임신급임신주기대FeNO수평무명현영향， AP환자FeNO수평명현승고，FeNO수평여폐공능무명현상관。
Objective To assess the changes of fractional concentration of exhaled NO (FeNO) in women of different gestation periods and in asthmatic pregnant women. Methods Forty six healthy pregnant women(HP group) and 30 non- preg-nant healthy women (HNP group), and 30 non- pregnant asthmatic women (ANP group) and 26 pregnant asthmatic women (AP group) were enrolled in the study. The FeNO levels in 4 groups and in different gestation periods of HP group were evaluated. The correlations of FeNO level with forced expiratory volume in the first second (FEV1)/predicted FEV1 (FEV1%) and peak expiratory flow (PEF)/predicted PEF (PEF%) values in AP group were analyzed. Results The values of FEV1%and PEF%were significant-ly decreased and the FeNO levels were elevated in AP and ANP groups as compared to HNP and HP groups (P<0.05). No sig-nificant differences of FeNO levels and FEV1%and PEF%values between HNP and HP groups or between ANP and AP groups were found (P>0.05). There were no significant differences in FeNO levels among different gestation periods in HP group (P>0.05) and no significant correlations of FeNO levels with FEV1%and FeNO values in AP group were revealed (r=0.250, 0.272, re-spectively, P>0.05). Conclusion FeNO level may not be influenced by pregnancy status and different gestation period; the FeNO level is increased in asthmatic pregnant women, however, it may not be correlated with the pulmonary function.