中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
5期
763-766
,共4页
刘香玉%田民强%冯丽莉%王湘%张东星%张微%刘甜甜%彭金娥%孙燕%王玥琦
劉香玉%田民彊%馮麗莉%王湘%張東星%張微%劉甜甜%彭金娥%孫燕%王玥琦
류향옥%전민강%풍려리%왕상%장동성%장미%류첨첨%팽금아%손연%왕모기
复方解郁颗粒%薄层色谱法%高效液相色谱法%质量标准
複方解鬱顆粒%薄層色譜法%高效液相色譜法%質量標準
복방해욱과립%박층색보법%고효액상색보법%질량표준
Compound Jieyu granules%TLC%HPLC%Quality standard
目的：建立复方解郁颗粒的质量标准,为该制剂的质量控制提供依据。方法：采用薄层色谱法对复方解郁颗粒中的丹皮进行鉴别,采用高效液相色谱法测定复方解郁颗粒中的柴胡皂苷a、柴胡皂苷d和芦丁的含量。结果：本品TLC色谱斑点清晰,重复性好；HPLC法测定柴胡皂苷 a、柴胡皂苷 d和芦丁线性范围分别为0.508~16.200μg(r=0.9998),0.503~16.100μg(r=0.9997)和0.130~4.250μg(r =0.9999)；平均加样回收率分别为99.7%(RSD =2.03%),99.8%(RSD =1.44%)和102.6%(RSD=1.40%)。结论：该方法简便,重复性好,结果准确可靠,可用于控制复方解郁颗粒的质量。
目的：建立複方解鬱顆粒的質量標準,為該製劑的質量控製提供依據。方法：採用薄層色譜法對複方解鬱顆粒中的丹皮進行鑒彆,採用高效液相色譜法測定複方解鬱顆粒中的柴鬍皂苷a、柴鬍皂苷d和蘆丁的含量。結果：本品TLC色譜斑點清晰,重複性好；HPLC法測定柴鬍皂苷 a、柴鬍皂苷 d和蘆丁線性範圍分彆為0.508~16.200μg(r=0.9998),0.503~16.100μg(r=0.9997)和0.130~4.250μg(r =0.9999)；平均加樣迴收率分彆為99.7%(RSD =2.03%),99.8%(RSD =1.44%)和102.6%(RSD=1.40%)。結論：該方法簡便,重複性好,結果準確可靠,可用于控製複方解鬱顆粒的質量。
목적：건립복방해욱과립적질량표준,위해제제적질량공제제공의거。방법：채용박층색보법대복방해욱과립중적단피진행감별,채용고효액상색보법측정복방해욱과립중적시호조감a、시호조감d화호정적함량。결과：본품TLC색보반점청석,중복성호；HPLC법측정시호조감 a、시호조감 d화호정선성범위분별위0.508~16.200μg(r=0.9998),0.503~16.100μg(r=0.9997)화0.130~4.250μg(r =0.9999)；평균가양회수솔분별위99.7%(RSD =2.03%),99.8%(RSD =1.44%)화102.6%(RSD=1.40%)。결론：해방법간편,중복성호,결과준학가고,가용우공제복방해욱과립적질량。
Objective:To establish the quality control method for compound Jieyu granules. Methods:Liquorice was identified by TLC. saikosaponin a, Saikosaponin d and rutin were determined by HPLC. Results:The spots on TLC plates were clear without any in-terference. The linearity was achieved within the range of 0. 508-16. 200 μg (r=0. 999 8) for saikosaponin a, 0. 503-16. 100 μg(r=0.999 7) for saikosaponin d, and 0.130-4.250 μg(r =0.999 9) for rutin. The average recovery was 99.7%(RSD =2.03%), 99. 8%(RSD=1. 44%) and 102. 6%(RSD=1. 40%), respectively. Conclusion:The method is simple, reliable and accurate, and can be applied as the quality control method for compound Jieyu granules.
