CAJ | 학술논문

目的：建立复方解郁颗粒的质量标准,为该制剂的质量控制提供依据。方法：采用薄层色谱法对复方解郁颗粒中的丹皮进行鉴别,采用高效液相色谱法测定复方解郁颗粒中的柴胡皂苷a、柴胡皂苷d和芦丁的含量。结果：本品TLC色谱斑点清晰,重复性好；HPLC法测定柴胡皂苷 a、柴胡皂苷 d和芦丁线性范围分别为0.508~16.200μg(r=0.9998),0.503~16.100μg(r=0.9997)和0.130~4.250μg(r =0.9999)；平均加样回收率分别为99.7%(RSD =2.03%),99.8%(RSD =1.44%)和102.6%(RSD=1.40%)。结论：该方法简便,重复性好,结果准确可靠,可用于控制复方解郁颗粒的质量。
목적：건립복방해욱과립적질량표준,위해제제적질량공제제공의거。방법：채용박층색보법대복방해욱과립중적단피진행감별,채용고효액상색보법측정복방해욱과립중적시호조감a、시호조감d화호정적함량。결과：본품TLC색보반점청석,중복성호；HPLC법측정시호조감 a、시호조감 d화호정선성범위분별위0.508~16.200μg(r=0.9998),0.503~16.100μg(r=0.9997)화0.130~4.250μg(r =0.9999)；평균가양회수솔분별위99.7%(RSD =2.03%),99.8%(RSD =1.44%)화102.6%(RSD=1.40%)。결론：해방법간편,중복성호,결과준학가고,가용우공제복방해욱과립적질량。
Objective:To establish the quality control method for compound Jieyu granules. Methods:Liquorice was identified by TLC. saikosaponin a, Saikosaponin d and rutin were determined by HPLC. Results:The spots on TLC plates were clear without any in-terference. The linearity was achieved within the range of 0. 508-16. 200 μg (r=0. 999 8) for saikosaponin a, 0. 503-16. 100 μg(r=0.999 7) for saikosaponin d, and 0.130-4.250 μg(r =0.999 9) for rutin. The average recovery was 99.7%(RSD =2.03%), 99. 8%(RSD=1. 44%) and 102. 6%(RSD=1. 40%), respectively. Conclusion:The method is simple, reliable and accurate, and can be applied as the quality control method for compound Jieyu granules.