CAJ | 학술논문

目的：探讨精神分裂症复发再入院的影响因素，研究重性精神疾病管理治疗对精神分裂症复发再入院的干预效果。方法以2007年首次发病在本院住院治疗的368例精神分裂症患者为研究对象，使用生活事件量表(LES)、社会支持评定量表(SSRS)、自编调查表等对复发因素进行Logistic回归分析。在此基础上分为抗精神病药物开放治疗对照组(对照组，n=184)和重性精神疾病管理治疗干预组(干预组，n=184)，观察5年来重性精神疾病管理治疗对精神分裂症复发再入院的影响。结果单因素回归分析显示，年龄、婚姻、家族史与精神分裂症复发再入院不相关(P>0.05)。性别、未治疗的精神病期(DUP)、负性生活事件是复发再入院的危险性因素(P<0.05)；受教育程度、服药依从性、社会支持是精神分裂症复发再入院的保护性因素(P<0.05)。多因素回归分析显示，服药依从性、社会支持、负性生活事件是复发再入院的主要影响因素(P<0.05)。5年来干预组的复发再入院率较对照组下降(P<0.05)。结论服药依从性、社会支持、负性生活事件是精神分裂症复发再入院的主要影响因素，重性精神疾病管理治疗干预是降低复发再入院率的重要措施。
목적：탐토정신분렬증복발재입원적영향인소，연구중성정신질병관리치료대정신분렬증복발재입원적간예효과。방법이2007년수차발병재본원주원치료적368례정신분렬증환자위연구대상，사용생활사건량표(LES)、사회지지평정량표(SSRS)、자편조사표등대복발인소진행Logistic회귀분석。재차기출상분위항정신병약물개방치료대조조(대조조，n=184)화중성정신질병관리치료간예조(간예조，n=184)，관찰5년래중성정신질병관리치료대정신분렬증복발재입원적영향。결과단인소회귀분석현시，년령、혼인、가족사여정신분렬증복발재입원불상관(P>0.05)。성별、미치료적정신병기(DUP)、부성생활사건시복발재입원적위험성인소(P<0.05)；수교육정도、복약의종성、사회지지시정신분렬증복발재입원적보호성인소(P<0.05)。다인소회귀분석현시，복약의종성、사회지지、부성생활사건시복발재입원적주요영향인소(P<0.05)。5년래간예조적복발재입원솔교대조조하강(P<0.05)。결론복약의종성、사회지지、부성생활사건시정신분렬증복발재입원적주요영향인소，중성정신질병관리치료간예시강저복발재입원솔적중요조시。
Objective To explore the factors related with relapse of patients with schizophrenia, and to assess the effect of management on this population. Methods 368 patients who were first episode and hospitalization in 2007 were recruited, and investigated with the Live Events Scale (LES), Social Support Rating Scale (SSRS). They were divided into control group (only antipsychotic treatment, n=184) and management group (severe mental illness management, n=184) and accepted the management for 5 years. Results The single factor regres-sion showed that age, marriage and family history were not related with schizophrenia relapse (P>0.05). Gender, duration of untreated psy-chosis (DUP) and negative life events were risk factors of relapse (P<0.05);Education, medication adherence and social support were protec-tive factors of relapse (P<0.05). Multivariate regression analysis showed that medication adherence, social support and negative life events were the main factors related with relapse (P<0.05). The rate of relapse was lower in the management group than in the control group (P<0.05). Conclusion Medication adherence, social support and negative life events are the main factors related with relapse. Management on the schizophrenia is one of the most important ways to reduce schizophrenia relapse.