实用检验医师杂志
實用檢驗醫師雜誌
실용검험의사잡지
Chinese Journal of Laboratory Pathologist
2014年
3期
164-167
,共4页
覃彦平%柯柳华%蒋义生%马兴璇
覃彥平%柯柳華%蔣義生%馬興璇
담언평%가류화%장의생%마흥선
慢性乙型肝炎%乙肝表面抗原%乙型肝炎病毒DNA%乙型肝炎核心抗原%丙氨酸转氨酶
慢性乙型肝炎%乙肝錶麵抗原%乙型肝炎病毒DNA%乙型肝炎覈心抗原%丙氨痠轉氨酶
만성을형간염%을간표면항원%을형간염병독DNA%을형간염핵심항원%병안산전안매
Chronic hepatitis B%Hepatitis B surface antigen%Hepatitis B virus DNA%Hepatitis B core antigen%Alanine aminotransferase
目的:回顾性分析慢性乙型肝炎(chronic hepatitis B, CHB)患者血清乙型肝炎表面抗原(hepatitis B surface antigen, HBsAg)定量与HBV DNA水平的相关性,并确定最佳的用于确定高HBV DNA水平的HBsAg定量值的诊断临界点。方法收集2013年7月至2014年5月期间柳州市中医院确诊为CHB的患者239例,检测受试者HBV DNA、HBsAg、HBeAg及ALT水平,对检测结果进行统计学分析。结果 HBeAg阳性组CHB患者HBsAg定量和HBV DNA检测水平均高于HBeAg阴性组,且差异均有统计学意义(P均<0.05)。所有CHB患者中HBsAg定量与HBV DNA水平之间呈正相关性(r=0.603,P<0.01)。HBeAg阳性组HBsAg定量与HBV DNA水平之间呈正相关性(r=0.555,P=0.000), HBeAg阴性组HBsAg定量与HBV DNA水平之间无相关性(r=0.076,P=0.426)。在抗病毒治疗前组和治疗后组中,HBsAg定量与HBV DNA水平均有较好的正相关性(r=0.622,r=0.603,P均=0.000)。在ALT 高水平组与ALT 低水平组中,HBsAg 定量和 HBV DNA 水平之间都存在正相关性(r=0.586,r=0.578,P均=0.000)。高DNA组(>2000 copies/L)患者的HBsAg定量和HBV DNA水平之间呈正相关性(r=0.637,P=0.000),低DNA组(<2000 copies/L)患者的HBsAg定量和HBV DNA水平之间无相关性(r=0.226,P=0.057)。当HBsAg定量以5.03×103 IU/mL为临界点时,判定HBV DNA高水平的受试者工作特征曲线下面积最大,为0.727。结论 CHB患者血清HBsAg定量值与HBV DNA水平呈正相关。血清HBsAg定量值可以较好地预测高HBV DNA水平。
目的:迴顧性分析慢性乙型肝炎(chronic hepatitis B, CHB)患者血清乙型肝炎錶麵抗原(hepatitis B surface antigen, HBsAg)定量與HBV DNA水平的相關性,併確定最佳的用于確定高HBV DNA水平的HBsAg定量值的診斷臨界點。方法收集2013年7月至2014年5月期間柳州市中醫院確診為CHB的患者239例,檢測受試者HBV DNA、HBsAg、HBeAg及ALT水平,對檢測結果進行統計學分析。結果 HBeAg暘性組CHB患者HBsAg定量和HBV DNA檢測水平均高于HBeAg陰性組,且差異均有統計學意義(P均<0.05)。所有CHB患者中HBsAg定量與HBV DNA水平之間呈正相關性(r=0.603,P<0.01)。HBeAg暘性組HBsAg定量與HBV DNA水平之間呈正相關性(r=0.555,P=0.000), HBeAg陰性組HBsAg定量與HBV DNA水平之間無相關性(r=0.076,P=0.426)。在抗病毒治療前組和治療後組中,HBsAg定量與HBV DNA水平均有較好的正相關性(r=0.622,r=0.603,P均=0.000)。在ALT 高水平組與ALT 低水平組中,HBsAg 定量和 HBV DNA 水平之間都存在正相關性(r=0.586,r=0.578,P均=0.000)。高DNA組(>2000 copies/L)患者的HBsAg定量和HBV DNA水平之間呈正相關性(r=0.637,P=0.000),低DNA組(<2000 copies/L)患者的HBsAg定量和HBV DNA水平之間無相關性(r=0.226,P=0.057)。噹HBsAg定量以5.03×103 IU/mL為臨界點時,判定HBV DNA高水平的受試者工作特徵麯線下麵積最大,為0.727。結論 CHB患者血清HBsAg定量值與HBV DNA水平呈正相關。血清HBsAg定量值可以較好地預測高HBV DNA水平。
목적:회고성분석만성을형간염(chronic hepatitis B, CHB)환자혈청을형간염표면항원(hepatitis B surface antigen, HBsAg)정량여HBV DNA수평적상관성,병학정최가적용우학정고HBV DNA수평적HBsAg정량치적진단림계점。방법수집2013년7월지2014년5월기간류주시중의원학진위CHB적환자239례,검측수시자HBV DNA、HBsAg、HBeAg급ALT수평,대검측결과진행통계학분석。결과 HBeAg양성조CHB환자HBsAg정량화HBV DNA검측수평균고우HBeAg음성조,차차이균유통계학의의(P균<0.05)。소유CHB환자중HBsAg정량여HBV DNA수평지간정정상관성(r=0.603,P<0.01)。HBeAg양성조HBsAg정량여HBV DNA수평지간정정상관성(r=0.555,P=0.000), HBeAg음성조HBsAg정량여HBV DNA수평지간무상관성(r=0.076,P=0.426)。재항병독치료전조화치료후조중,HBsAg정량여HBV DNA수평균유교호적정상관성(r=0.622,r=0.603,P균=0.000)。재ALT 고수평조여ALT 저수평조중,HBsAg 정량화 HBV DNA 수평지간도존재정상관성(r=0.586,r=0.578,P균=0.000)。고DNA조(>2000 copies/L)환자적HBsAg정량화HBV DNA수평지간정정상관성(r=0.637,P=0.000),저DNA조(<2000 copies/L)환자적HBsAg정량화HBV DNA수평지간무상관성(r=0.226,P=0.057)。당HBsAg정량이5.03×103 IU/mL위림계점시,판정HBV DNA고수평적수시자공작특정곡선하면적최대,위0.727。결론 CHB환자혈청HBsAg정량치여HBV DNA수평정정상관。혈청HBsAg정량치가이교호지예측고HBV DNA수평。
Objective To analysis the relevance of the serum HBsAg and HBV DNA levels in patients with chronic hepatitis B (CHB), and to detect the HBsAg critical point levels used to determine the best high HBV DNA. Methods 239 cases CHB patients in Liuzhou Traditional Chinese Medicine Hospital from July 2013 to May 2014 were collected. The levels of HBV DNA, HBsAg, HBeAg and ALT were detected. The results were analyzed statistically. Results The levels of HBsAg and HBV DNA in HBeAg positive group were all higher than that of HBeAg negative group, and the differences all had statistical significance (Pall<0.05). The levels of HBsAg and HBV DNA were positive correlated in all the CHB patients (r=0.603, P<0.01). The levels of HBsAg and HBV DNA were positive correlated in HBeAg positive group (r=0.555, P=0.000), but there was no correlation in HBeAg negative group (r=0.076,P=0.426). The levels of HBsAg and HBV DNA were all positive correlated in before antiviral therapy group and after antiviral therapy group (r=0.622, r=0.603, Pall=0.000). The levels of HBsAg and HBV DNA were all positive correlated in high ALT group and low ALT group(r=0.586,r=0.578, Pall=0.000). The levels of HBsAg and HBV DNA were positive correlated in high HBV DNA (>2000 copies/L) group (r=0.637, P=0.000), but there was no correlation in low HBV DNA(<2000 copies/L) group(r=0.226, P=0.057). HBsAg levels used to determine the best high HBV DNA critical point was 5.03 × 103 IU/mL, and the area under receiver operating characteristic curve was 0.727. Conclusion There are positive correlation between serum HBsAg and HBV DNA levels in CHB patients. HBsAg levels can be used for speculated the high levels of serum HBV DNA levels.