CAJ | 학술논문

目的：探讨性激素17β-羟甾类固醇脱氢酶（HSD17B1和HSD17B2）基因单核苷酸多态性与四川地区汉族人群肝癌之间的关系，为肝癌的预防、筛查、治疗及预后提供理论依据。方法以136例汉族肝癌患者，200例汉族健康人群为对象，选取HSD17B1 rs676387、HSD17B2 rs8191246两个位点作为遗传标志，采用聚合酶链反应-限制性片段长度多态技术检测 HSD17B1和 HSD17B2基因多态性及其分布频率。结果与健康人群相比HSD17B1 rs676387的T等位基因显著增加肝癌患病风险（P＜0．05）。结论 HSD17B1 rs676387与四川汉族 HCC的发生发展具有相关性，该研究结果有待在多民族、多中心、大样本研究中进一步证实。
목적：탐토성격소17β-간치류고순탈경매（HSD17B1화HSD17B2）기인단핵감산다태성여사천지구한족인군간암지간적관계，위간암적예방、사사、치료급예후제공이론의거。방법이136례한족간암환자，200례한족건강인군위대상，선취HSD17B1 rs676387、HSD17B2 rs8191246량개위점작위유전표지，채용취합매련반응-한제성편단장도다태기술검측 HSD17B1화 HSD17B2기인다태성급기분포빈솔。결과여건강인군상비HSD17B1 rs676387적T등위기인현저증가간암환병풍험（P＜0．05）。결론 HSD17B1 rs676387여사천한족 HCC적발생발전구유상관성，해연구결과유대재다민족、다중심、대양본연구중진일보증실。
Objective Toinvestigatetheassociationbetweenthesexhormone17β-hydroxysteroid dehydrogenase (HSD17B1 and HSD17B2)gene single nucleotide polymorphisms in Sichuan Han population withHCC(Hepatocellularcarcinoma).Methods 136casesofHCCand200healthycontrolsubjects were enrolled in present study.Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)methods were chosen to genotype the HSD17B1 rs676387 and HSD17B2 rs8191246 single nucleotide polymorphisms.Results TherewasstatisticallysignificantdifferencebetweenHCCpatientsHSD17B1 rs676387 and normal control groups (P <0.05 ). Conclusion HSD17B1 rs676387 polymorphisms increased the susceptibility of HCC in the Sichuan Han population. Those findings should be further confirmed in a large sample of multi-ethnic multi-center study.