白血病·淋巴瘤
白血病·淋巴瘤
백혈병·림파류
JOURNAL OF LEUKEMIA & LYMPHOMA
2013年
10期
632-634
,共3页
白血病,髓系,急性%IDH1/2基因突变
白血病,髓繫,急性%IDH1/2基因突變
백혈병,수계,급성%IDH1/2기인돌변
Leukemia,myeloid,acute%IDH1/2 gene mutations
急性髓系白血病(AML)是一组以染色体异常和(或)基因突变为特征的恶性肿瘤.其发病机制十分复杂.最近,测序发现了一种编码代谢酶IDH1/2基因的高频突变.这一发现激起了国内外研究小组的兴趣,进行了一系列的临床和基础研究.文章对这些研究进行综述.
急性髓繫白血病(AML)是一組以染色體異常和(或)基因突變為特徵的噁性腫瘤.其髮病機製十分複雜.最近,測序髮現瞭一種編碼代謝酶IDH1/2基因的高頻突變.這一髮現激起瞭國內外研究小組的興趣,進行瞭一繫列的臨床和基礎研究.文章對這些研究進行綜述.
급성수계백혈병(AML)시일조이염색체이상화(혹)기인돌변위특정적악성종류.기발병궤제십분복잡.최근,측서발현료일충편마대사매IDH1/2기인적고빈돌변.저일발현격기료국내외연구소조적흥취,진행료일계렬적림상화기출연구.문장대저사연구진행종술.
Acute myeloid leukemia is a group of malignant tumor characterized by chromosome abnormality and/or gene mutations.Its pathogenesis is very complex.Gene mutations in IDH1/2 which encode metabolic enzyme were found by sequencing recently.This discovery aroused interest in the domestic and foreign research group.A series of clinical and basic research was also conducted.This review is based on these studies.
