山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
22期
11-13
,共3页
孙琳%刘爱武%李凯%刘波%于海华%赵鸿鹏
孫琳%劉愛武%李凱%劉波%于海華%趙鴻鵬
손림%류애무%리개%류파%우해화%조홍붕
骨髓相关蛋白-14%胃癌%免疫组织化学%临床病理特征
骨髓相關蛋白-14%胃癌%免疫組織化學%臨床病理特徵
골수상관단백-14%위암%면역조직화학%림상병리특정
myeloid-related protein-14%gastric carcinoma%immunohistochemistry%clinicopathological features
目的:观察胃癌组织中骨髓相关蛋白-14( S100 A9)的表达变化,探讨其与胃癌患者临床病理特征的关系。方法选择手术切除的胃癌组织标本82份为胃癌组,选择癌旁正常组织标本82份为对照组。采用免疫组织化学SP法,检测两组S100 A9蛋白的表达,分析S100 A9蛋白阳性与胃癌患者性别、年龄、肿瘤浸润深度、分化程度、淋巴结转移、病理分期、肿瘤直径等临床病理特征的关系。结果胃癌组S100 A9蛋白表达阳性率为59.8%(49/82),对照组为6.1%(5/82),胃癌组S100A9的表达阳性率高于对照组(P<0.05)。胃癌患者T3+T4期者S100A9蛋白的表达高于T1+T2期者,低分化者S100A9蛋白的表达高于高、中分化者,存在淋巴结转移者S100A9蛋白的表达高于无淋巴结转移者,病理分期Ⅲ+Ⅳ期者S100 A9蛋白的表达高于Ⅰ+Ⅱ期者( P均<0.05)。结论胃癌组织中S100 A9蛋白的表达明显上调,且与淋巴结转移、肿瘤浸润深度、临床分期、分化有关。
目的:觀察胃癌組織中骨髓相關蛋白-14( S100 A9)的錶達變化,探討其與胃癌患者臨床病理特徵的關繫。方法選擇手術切除的胃癌組織標本82份為胃癌組,選擇癌徬正常組織標本82份為對照組。採用免疫組織化學SP法,檢測兩組S100 A9蛋白的錶達,分析S100 A9蛋白暘性與胃癌患者性彆、年齡、腫瘤浸潤深度、分化程度、淋巴結轉移、病理分期、腫瘤直徑等臨床病理特徵的關繫。結果胃癌組S100 A9蛋白錶達暘性率為59.8%(49/82),對照組為6.1%(5/82),胃癌組S100A9的錶達暘性率高于對照組(P<0.05)。胃癌患者T3+T4期者S100A9蛋白的錶達高于T1+T2期者,低分化者S100A9蛋白的錶達高于高、中分化者,存在淋巴結轉移者S100A9蛋白的錶達高于無淋巴結轉移者,病理分期Ⅲ+Ⅳ期者S100 A9蛋白的錶達高于Ⅰ+Ⅱ期者( P均<0.05)。結論胃癌組織中S100 A9蛋白的錶達明顯上調,且與淋巴結轉移、腫瘤浸潤深度、臨床分期、分化有關。
목적:관찰위암조직중골수상관단백-14( S100 A9)적표체변화,탐토기여위암환자림상병리특정적관계。방법선택수술절제적위암조직표본82빈위위암조,선택암방정상조직표본82빈위대조조。채용면역조직화학SP법,검측량조S100 A9단백적표체,분석S100 A9단백양성여위암환자성별、년령、종류침윤심도、분화정도、림파결전이、병리분기、종류직경등림상병리특정적관계。결과위암조S100 A9단백표체양성솔위59.8%(49/82),대조조위6.1%(5/82),위암조S100A9적표체양성솔고우대조조(P<0.05)。위암환자T3+T4기자S100A9단백적표체고우T1+T2기자,저분화자S100A9단백적표체고우고、중분화자,존재림파결전이자S100A9단백적표체고우무림파결전이자,병리분기Ⅲ+Ⅳ기자S100 A9단백적표체고우Ⅰ+Ⅱ기자( P균<0.05)。결론위암조직중S100 A9단백적표체명현상조,차여림파결전이、종류침윤심도、림상분기、분화유관。
Objective To observe the expression changes of S 100 A9 protein ( myeloid-related protein-14 ) in human gastric cancer tissues, and to explore the relationship between S100A9 and clinicopathological features of gastric cancer . Methods Eighty-two cases of gastric cancer tissue samples ( gastric cancer group ) and 82 cases of paired adjacent tissues (control group) were chosen.The expression of S100A9 protein in the two groups was detected by immunohistochemistrial SP method, and we analyzed its relationship with patients'gender, age, depth of tumor invasion, degree of cell differentia-tion, lymph node metastasis , tumor stage and tumor size .Results The positive expression rate of S 100 A9 protein in the gastric cancer group was 59.8% (49/82), while 6.1% (5/82) in the control group.The positive expression rate of S100A9 in the gastric cancer group was significantly higher than that in the control group (P<0.05).The expression of S100A9 in stage T3 and T4, in poorly differentiated , in pathological staging Ⅲ+Ⅳ and with lymph node metastasis was higher than that of patients in stage T 1 and T2, in highly and moderately differentiated , in pathological staging I +II and without lymph node metastasis (all P<0.05).Conclusion The expression of S100A9 protein is significantly up-regula-ted in gastric cancer tissues , and is associated with lymph node metastasis , depth of tumor invasion , clinical stage and de-gree of differentiation .