CAJ | 학술논문

卵巢恶性肿瘤是死亡率最高的妇科恶性肿瘤。尽管标准化的治疗方法（包括理想的肿瘤细胞减灭术和以铂类／紫杉醇为基础的化疗方案）使得70％的患者得到一定程度的临床缓解，但绝大多数患者仍然会在2年内复发并出现耐药。肿瘤干细胞理论认为，肿瘤组织中有小部分细胞群体具有极强的增殖能力，它们具有类似正常干细胞的生物学特性，能通过自我更新和分化来高频度地启动肿瘤的发生发展，它们是导致肿瘤发生、发展、转移和耐药的主要细胞，是肿瘤复发的根源。该文将概述近几年卵巢癌干细胞的各项研究，包括卵巢癌干细胞的分离及其耐药机制、各种治疗方法等。
란소악성종류시사망솔최고적부과악성종류。진관표준화적치료방법（포괄이상적종류세포감멸술화이박류／자삼순위기출적화료방안）사득70％적환자득도일정정도적림상완해，단절대다수환자잉연회재2년내복발병출현내약。종류간세포이론인위，종류조직중유소부분세포군체구유겁강적증식능력，타문구유유사정상간세포적생물학특성，능통과자아경신화분화래고빈도지계동종류적발생발전，타문시도치종류발생、발전、전이화내약적주요세포，시종류복발적근원。해문장개술근궤년란소암간세포적각항연구，포괄란소암간세포적분리급기내약궤제、각충치료방법등。
Ovarian cancer is a gynecological malignant tumor with highest mortality .Although the standard treatment ( including cytoreductive surgery and platinum/paclitaxel-based chemotherapy ) has made 70%of ovarian cancer patients relieve , most of the patients relapse within two years and have drug resistance .The cancer stem cells ( CSCs ) theory explains that there is a small subgroup of tumor cells with strong ability to proliferate .They have similar biological capacities to normal stem cells , which can frequently initiate tumor regeneration and progress through self-renew. They are the major cells promoting tumor regeneration , progress, invasion and chemoresistance , and they are the primary cause of tumor recurrence .This article summarized different investigations on ovarian CSCs , including isolation , mechanisms of chemoresistance and therapeutic approaches .