中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
4期
678-680
,共3页
席卫平%朱镭%卫重侠%杨建平%任丽丽
席衛平%硃鐳%衛重俠%楊建平%任麗麗
석위평%주뢰%위중협%양건평%임려려
反复呼吸道感染%病例对照研究%儿童%T细胞亚群%自然杀伤细胞
反複呼吸道感染%病例對照研究%兒童%T細胞亞群%自然殺傷細胞
반복호흡도감염%병례대조연구%인동%T세포아군%자연살상세포
recurrent respiratory tract infections ( RRITs)%case-control study%children%T cell subset%NK cells
目的:了解3~6岁儿童反复呼吸道感染( RRTIs) T细胞亚群及自然杀伤细胞( NK)的变化,指导临床预防用药,避免过度以及不当治疗。方法严格按照入选标准和剔除标准收集3~6岁儿童160例,其中:病例组73例,对照组87例。采用病例对照研究。用流式细胞仪对病例组和对照组分别进行T细胞亚群、NK细胞的检测,并对有关数据进行统计分析。结果对T细胞亚群(CD3+、CD4+、CD8+、CD4+/CD8+)进行两独立样本的Wilcoxon秩和检验,结果表明:CD3+(z=-1.588,P=0.112)、CD4+(z=-0.541,P=0.588)、CD8+(z=-0.733,P=0.463)、CD4+/CD8+(z=-0.315,P=0.753)病例组和对照组比较差异均无统计学意义(均P>0.05)。对NK细胞( CD3-CD16+CD56+)进行t’检验( t’=2.779,P=0.006<0.05;95%CI:0.674~4.003),病例组和对照组比较差异有统计学意义。结论对RRTIs儿童检测T细胞亚群与NK细胞具有显著的临床指导意义,可避免过度使用免疫调节剂引起的用药不当。
目的:瞭解3~6歲兒童反複呼吸道感染( RRTIs) T細胞亞群及自然殺傷細胞( NK)的變化,指導臨床預防用藥,避免過度以及不噹治療。方法嚴格按照入選標準和剔除標準收集3~6歲兒童160例,其中:病例組73例,對照組87例。採用病例對照研究。用流式細胞儀對病例組和對照組分彆進行T細胞亞群、NK細胞的檢測,併對有關數據進行統計分析。結果對T細胞亞群(CD3+、CD4+、CD8+、CD4+/CD8+)進行兩獨立樣本的Wilcoxon秩和檢驗,結果錶明:CD3+(z=-1.588,P=0.112)、CD4+(z=-0.541,P=0.588)、CD8+(z=-0.733,P=0.463)、CD4+/CD8+(z=-0.315,P=0.753)病例組和對照組比較差異均無統計學意義(均P>0.05)。對NK細胞( CD3-CD16+CD56+)進行t’檢驗( t’=2.779,P=0.006<0.05;95%CI:0.674~4.003),病例組和對照組比較差異有統計學意義。結論對RRTIs兒童檢測T細胞亞群與NK細胞具有顯著的臨床指導意義,可避免過度使用免疫調節劑引起的用藥不噹。
목적:료해3~6세인동반복호흡도감염( RRTIs) T세포아군급자연살상세포( NK)적변화,지도림상예방용약,피면과도이급불당치료。방법엄격안조입선표준화척제표준수집3~6세인동160례,기중:병례조73례,대조조87례。채용병례대조연구。용류식세포의대병례조화대조조분별진행T세포아군、NK세포적검측,병대유관수거진행통계분석。결과대T세포아군(CD3+、CD4+、CD8+、CD4+/CD8+)진행량독립양본적Wilcoxon질화검험,결과표명:CD3+(z=-1.588,P=0.112)、CD4+(z=-0.541,P=0.588)、CD8+(z=-0.733,P=0.463)、CD4+/CD8+(z=-0.315,P=0.753)병례조화대조조비교차이균무통계학의의(균P>0.05)。대NK세포( CD3-CD16+CD56+)진행t’검험( t’=2.779,P=0.006<0.05;95%CI:0.674~4.003),병례조화대조조비교차이유통계학의의。결론대RRTIs인동검측T세포아군여NK세포구유현저적림상지도의의,가피면과도사용면역조절제인기적용약불당。
Objective To investigate the variations of T cell subset and NK cells in children aged 3-6 years old with recurrent respiratory tract infections ( RRTIs) , so as to provide new guidance for clinical preventive medication and avoid unreasonable therapy .Methods In a case-control study , 160 children aged 3-6 years old were selected strictly according to criterion , including 73 cases in case group and 87 cases in control group .The T cell subset and NK cells from peripheral blood of two groups were measured by flow cytometry method for data analysis .Results Wilcoxon rank-sum test on T cell subset showed that there was no significant difference between two groups in CD 3 +( z=-1.588, P=0.112), CD4 +(z=-0.541,P=0.588), CD8 +(z=-0.733, P=0.463) and CD4 +/CD8 +(z=-0.315, P=0.753) (all P>0.05).But there was significant difference in NK cells between two groups (t’ =2.779, P=0.006<0.05;95%CI:0.674-4.003).Conclusion Detecting T cell subset and NK cells in children with RRITs is very useful in clinics , which can avoid unreasonable medication caused by excessive immunoregulant .