中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
4期
612-614
,共3页
糖类抗原125%孕酮%人绒毛膜促性腺激素%雌二醇%异位妊娠
糖類抗原125%孕酮%人絨毛膜促性腺激素%雌二醇%異位妊娠
당류항원125%잉동%인융모막촉성선격소%자이순%이위임신
CA125%progesterone(P)%β-hCG%estradiol(E2)%ectopic pregnancy
目的：通过监测血清糖类抗原125（CA125）、孕酮（P）、人绒毛膜促性腺激素（β-hCG）和雌二醇（E2）的水平，探讨如何早期诊断异位妊娠。方法选取自2011年6月至2013年5月在衢化医院治疗的有异位妊娠症状的妇女40例为研究组、同期正常宫内妊娠妇女25例为对照组，运用酶联免疫法测定各组血清中的CA125、P、β-hCG和E2水平。结果血清中CA125、P、β-hCG和E2值在研究组中分别为：15．60±1．025IU／mL、19．98±1．997nmol／mL、61．36±2．096mIU／mL、21．12±1．508pg／mL；而在对照组中分别为46．36±3．538IU／mL、93．40±5．809nmol／mL、127．94±9．944mIU／mL、85．82±5．216pg／mL，两组各指标比较均具有显著性差异（t值分别为13．223、4．835、3．762、5．499，均P＜0．01）。若将CA125诊断异位妊娠的切割点定义为20．37IU／mL，则诊断异位妊娠的特异性和敏感性分别为96％与85％，阳性预测值与阴性预测值分别为85％、73％；若将P诊断异位妊娠的切割点定义为55．63nmol／mL，则诊断异位妊娠的特异性和敏感性分别为100％与88％，阳性预测值与阴性预测值分别为100％、83％。结论血清CA125、P可以作为预测或早期诊断异位妊娠临床较敏感的指标。
目的：通過鑑測血清糖類抗原125（CA125）、孕酮（P）、人絨毛膜促性腺激素（β-hCG）和雌二醇（E2）的水平，探討如何早期診斷異位妊娠。方法選取自2011年6月至2013年5月在衢化醫院治療的有異位妊娠癥狀的婦女40例為研究組、同期正常宮內妊娠婦女25例為對照組，運用酶聯免疫法測定各組血清中的CA125、P、β-hCG和E2水平。結果血清中CA125、P、β-hCG和E2值在研究組中分彆為：15．60±1．025IU／mL、19．98±1．997nmol／mL、61．36±2．096mIU／mL、21．12±1．508pg／mL；而在對照組中分彆為46．36±3．538IU／mL、93．40±5．809nmol／mL、127．94±9．944mIU／mL、85．82±5．216pg／mL，兩組各指標比較均具有顯著性差異（t值分彆為13．223、4．835、3．762、5．499，均P＜0．01）。若將CA125診斷異位妊娠的切割點定義為20．37IU／mL，則診斷異位妊娠的特異性和敏感性分彆為96％與85％，暘性預測值與陰性預測值分彆為85％、73％；若將P診斷異位妊娠的切割點定義為55．63nmol／mL，則診斷異位妊娠的特異性和敏感性分彆為100％與88％，暘性預測值與陰性預測值分彆為100％、83％。結論血清CA125、P可以作為預測或早期診斷異位妊娠臨床較敏感的指標。
목적：통과감측혈청당류항원125（CA125）、잉동（P）、인융모막촉성선격소（β-hCG）화자이순（E2）적수평，탐토여하조기진단이위임신。방법선취자2011년6월지2013년5월재구화의원치료적유이위임신증상적부녀40례위연구조、동기정상궁내임신부녀25례위대조조，운용매련면역법측정각조혈청중적CA125、P、β-hCG화E2수평。결과혈청중CA125、P、β-hCG화E2치재연구조중분별위：15．60±1．025IU／mL、19．98±1．997nmol／mL、61．36±2．096mIU／mL、21．12±1．508pg／mL；이재대조조중분별위46．36±3．538IU／mL、93．40±5．809nmol／mL、127．94±9．944mIU／mL、85．82±5．216pg／mL，량조각지표비교균구유현저성차이（t치분별위13．223、4．835、3．762、5．499，균P＜0．01）。약장CA125진단이위임신적절할점정의위20．37IU／mL，칙진단이위임신적특이성화민감성분별위96％여85％，양성예측치여음성예측치분별위85％、73％；약장P진단이위임신적절할점정의위55．63nmol／mL，칙진단이위임신적특이성화민감성분별위100％여88％，양성예측치여음성예측치분별위100％、83％。결론혈청CA125、P가이작위예측혹조기진단이위임신림상교민감적지표。
Objective To investigate how to diagnose ectopic pregnancy early by monitoring the serum levels of CA 125, progesterone (P),β-hCG and estradiol (E2).Methods Serum levels of CA125, P, β-hCG and E2 were measured by enzyme-linked immunosorbent assay (ELISA) in 40 women with ectopic pregnancy and 25 women with normal intrauterine pregnancy in Zhejiang Quhua Hospital between June 2011 and May 2013.Results The serum levels of CA125, P,β-hCG and E2 in study group were 15.60 ±1.025IU/mL, 19.98 ±1.997 nmol/mL, 61.36 ±2.096mIU/mL and 21.12 ±1.508pg/mL, respectively, and they were 46.36 ±3.538IU/mL, 93.40 ±5.809nmol/mL, 127.94 ±9.944mIU/mL and 85.82 ±5.216pg/mL, respectively in control group .There were significant differences between two groups (t value was 13.223, 4.835, 3.762 and 5.499, respectively, all P<0.01).When using CA125 concentration of 20.37IU/mL as cut-off value for diagnosis or prediction of ectopic pregnancy , the specificity was 96% and the sensitivity was 85%, and the positive and negative predictive value was 85%and 73%, respectively.When using progesterone concentration of 55.63nmol/ml as cut-off value for diagnosis of ectopic pregnancy , the sensitivity was 88%and the specificity was 100%, and the positive and negative predictive value was 100%and 83%, respectively .Conclusion The serum levels of CA125 and P can be taken as sensitive indexes to predict and diagnose ectopic pregnancy .
