中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2014年
4期
600-602
,共3页
李秀云%古家常%李海燕%陈陪茹
李秀雲%古傢常%李海燕%陳陪茹
리수운%고가상%리해연%진배여
β2微球蛋白%胱抑素C%高胆红素血症%肾脏损害
β2微毬蛋白%胱抑素C%高膽紅素血癥%腎髒損害
β2미구단백%광억소C%고담홍소혈증%신장손해
β2 microglobulin (β2-MG)%cystatin C(CysC)%hyperbilirubinemia%kidney damage
目的：探讨血清β2微球蛋白（β2-MG）和胱抑素C（ Cys C）检测在新生儿高胆红素血症肾损害诊断中的价值。方法检测72例高胆红素血症患儿（观察组）及30例非高胆红素血症新生儿（对照组）的血清总胆红素（ TBil）、β2-MG、Cys C、肌酐（Cr）和尿素氮（BUN）的含量，比较两组之间及观察组轻度、中重度患儿之间的检测结果，比较观察组治疗前后血清TBil、β2-MG、Cys C水平和治疗后观察组和对照组血清β2-MG、Cys C水平。结果观察组血清TBil、β2-MG、CysC水平均高于对照组，差异有统计学意义（t值分别为42．71、41．10和8．47，均P＜0．05）；观察组轻度患儿TBil、β2-MG、CysC水平均低于中重度患儿，差异有统计学意义（t值分别为9．96、14．16和8．08，均P＜0．05）；治疗后观察组血清TBil、β2-MG、CysC水平均较治疗前明显下降，差异有统计学意义（t值分别为65．46、54．21和14．18，均P＜0．05）；血清β2-MG、CysC水平与TBil水平成正相关（r值分别为0．81和0．53，均P＜0．05），BUN、Cr水平与TBil水平无相关性（r值分别为0．21和0．16，均P＞0．05）。结论血清β2-MG、CysC水平检测能够准确反应肾脏功能损伤情况，可作为高胆红素血症患儿肾损伤的敏感的准确指标，对病情的评估及临床疗效的判断也具有重要价值。
目的：探討血清β2微毬蛋白（β2-MG）和胱抑素C（ Cys C）檢測在新生兒高膽紅素血癥腎損害診斷中的價值。方法檢測72例高膽紅素血癥患兒（觀察組）及30例非高膽紅素血癥新生兒（對照組）的血清總膽紅素（ TBil）、β2-MG、Cys C、肌酐（Cr）和尿素氮（BUN）的含量，比較兩組之間及觀察組輕度、中重度患兒之間的檢測結果，比較觀察組治療前後血清TBil、β2-MG、Cys C水平和治療後觀察組和對照組血清β2-MG、Cys C水平。結果觀察組血清TBil、β2-MG、CysC水平均高于對照組，差異有統計學意義（t值分彆為42．71、41．10和8．47，均P＜0．05）；觀察組輕度患兒TBil、β2-MG、CysC水平均低于中重度患兒，差異有統計學意義（t值分彆為9．96、14．16和8．08，均P＜0．05）；治療後觀察組血清TBil、β2-MG、CysC水平均較治療前明顯下降，差異有統計學意義（t值分彆為65．46、54．21和14．18，均P＜0．05）；血清β2-MG、CysC水平與TBil水平成正相關（r值分彆為0．81和0．53，均P＜0．05），BUN、Cr水平與TBil水平無相關性（r值分彆為0．21和0．16，均P＞0．05）。結論血清β2-MG、CysC水平檢測能夠準確反應腎髒功能損傷情況，可作為高膽紅素血癥患兒腎損傷的敏感的準確指標，對病情的評估及臨床療效的判斷也具有重要價值。
목적：탐토혈청β2미구단백（β2-MG）화광억소C（ Cys C）검측재신생인고담홍소혈증신손해진단중적개치。방법검측72례고담홍소혈증환인（관찰조）급30례비고담홍소혈증신생인（대조조）적혈청총담홍소（ TBil）、β2-MG、Cys C、기항（Cr）화뇨소담（BUN）적함량，비교량조지간급관찰조경도、중중도환인지간적검측결과，비교관찰조치료전후혈청TBil、β2-MG、Cys C수평화치료후관찰조화대조조혈청β2-MG、Cys C수평。결과관찰조혈청TBil、β2-MG、CysC수평균고우대조조，차이유통계학의의（t치분별위42．71、41．10화8．47，균P＜0．05）；관찰조경도환인TBil、β2-MG、CysC수평균저우중중도환인，차이유통계학의의（t치분별위9．96、14．16화8．08，균P＜0．05）；치료후관찰조혈청TBil、β2-MG、CysC수평균교치료전명현하강，차이유통계학의의（t치분별위65．46、54．21화14．18，균P＜0．05）；혈청β2-MG、CysC수평여TBil수평성정상관（r치분별위0．81화0．53，균P＜0．05），BUN、Cr수평여TBil수평무상관성（r치분별위0．21화0．16，균P＞0．05）。결론혈청β2-MG、CysC수평검측능구준학반응신장공능손상정황，가작위고담홍소혈증환인신손상적민감적준학지표，대병정적평고급림상료효적판단야구유중요개치。
Objective To investigate the value of serum β2-microglobulin (β2-MG) and cystatin C ( CysC) in diagnosing renal impairment in newborns with hyperbilirubinemia.Methods Serum total bilirubin (TBil), β2-MG, CysC, creatinine (Cr) and blood urea nitrogen ( BUN) contents of 72 newborns with hyperbilirubinemia ( observation group ) and 30 newborns without hyperbilirubinemia ( control group ) were detected , and the above results were compared between two groups and between the mild , moderately severe patient of the observation group.Serum TBil,β2-MG and CysC levels of the observation group before and after treatment were compared , and serum β2-MG and CysC levels of the two groups before and after treatment were compared .Results The serum TBil , β2-MG and CysC levels of the observation group were higher than the control group (t value was 42.71, 41.10 and 8.47, respectively, all P<0.05).TBil,β2-MG and CysC levels of the mild patients in the observation group were lower than those of the moderately severe patients (t value were 9.96, 14.16 and 8.08, respectively, all P<0.05).The serum TBil,β2-MG and CysC levels were significantly decreased after treatment (t value was 65.46, 54.21 and 14.18, respectively, all P<0.05).The serum β2-MG and CysC levels were positively correlated with TBil level (r value was 0.81 and 0.53, respectively, both P<0.05), but BUN and Cr levels had no correlation with TBil level (r value wad 0.21 and 0.16, respectively, both P>0.05).Conclusion The detection of serum β2-MG and CysC levels can accurately reflect the renal function damage, and they can be considered as the accurate and sensitive indexes for renal impairment in newborns with hyperbilirubinemia .They also have an important value for evaluation of the disease and judgment for clinical curative effect .
