CAJ | 학술논문

目的：分析伴有软骨基质分泌的乳腺化生性癌的临床病理学特征、免疫组化标记特点及其组织起源。方法收集5例伴软骨基质分泌的乳腺化生性癌的临床及随访资料，观察组织病理形态学及免疫组化标记，并对相关文献进行复习。结果5例患者年龄37～48岁，组织标本切面灰黄或灰褐色，结节状，界限尚清。镜下见肿瘤细胞围绕软骨粘液样或透明软骨样基质呈巢状，条索状排列，密集的瘤细胞可聚集于周边，中央区细胞稀疏，周边肿瘤细胞向基质移行中无梭形细胞肉瘤样成份。免疫组化结果显示，5例均同时表达CK、Vim及S-100，但不表达ER、PR、Her-2。结论伴有软骨基质分化的乳腺化生性癌是一种罕见肿瘤，具有特征性的病理组织形态和免疫表型，临床过程与普通非特异性浸润性乳腺癌无异。
목적：분석반유연골기질분비적유선화생성암적림상병이학특정、면역조화표기특점급기조직기원。방법수집5례반연골기질분비적유선화생성암적림상급수방자료，관찰조직병리형태학급면역조화표기，병대상관문헌진행복습。결과5례환자년령37～48세，조직표본절면회황혹회갈색，결절상，계한상청。경하견종류세포위요연골점액양혹투명연골양기질정소상，조색상배렬，밀집적류세포가취집우주변，중앙구세포희소，주변종류세포향기질이행중무사형세포육류양성빈。면역조화결과현시，5례균동시표체CK、Vim급S-100，단불표체ER、PR、Her-2。결론반유연골기질분화적유선화생성암시일충한견종류，구유특정성적병리조직형태화면역표형，림상과정여보통비특이성침윤성유선암무이。
Objective To analyze the clinicopathological and immunohistochemical phenotypic features and origions of breast matrix -producing metaplastic carcinoma ( MPC) .Methods Clinical and follow-up data of 5 patients with MPC were collected .The histopathology was observed with H&E staining under light microscopy , and immunohistochemical staining was carried out for the immunophenotype evaluation.The related literatures were reviewed .Results The age of 5 patients ranged from 37 to 48 year.The neoplasms were nodular , and the cut surfaces were yellow or brown in color .Histopathologically , the tumors showed a well-circumscribed , nodular lesion composed of peripheral collections of tumor cells arranged in nests and /or cords extending into a central area of cartilage or hyaline cartilage-like matrix.No intervening spindle cell component was present between the carcinoma and the matrix material .Metaplastic carcinoma cells merged from cellular periphery of tumor to matrix-rich central portion .Immunohistochemically , 5 cases were positive of CK , Vim and S-100 but negative of ER , PR and Her-2.Conclusion MPC of breast cancer is an extremely rare variant of metaplastic carcinoma .MPC has featured pathohistological morphology and immunophenotypes and similar clinical characteristics with general non -specific breast cancer .