CAJ | 학술논문

目的：通过测定溃疡性结肠炎患者外周血清NO（nitricoxide）、P-选择素（P-selectin），探讨两者在溃疡性结肠炎发病中的相互关系。方法 UC患者60例，其中活动组（n=41），缓解组（n=19）,并取同期健康体检者（n=20）作为对照组；取清晨空腹血液以检测其NO、P-selectin、白细胞（WBC）、血小板（ PLT）水平。结果 UC活动组的血清中NO、P-selectin水平明显高于缓解组和对照组，差异均具有显著性（P＜0.01）,而缓解组、对照组两组间无统计学差异（P＞0.05），只有活动组中P-selectin与NO的表达存在正相关性（r=0.51,P＜0.01）。UC活动组血清中WBC、PLT水平明显高于对照组及缓解组（P＜0.01）。结论在UC疾病的发病中,P-selectin与NO可能有协同作用。
목적：통과측정궤양성결장염환자외주혈청NO（nitricoxide）、P-선택소（P-selectin），탐토량자재궤양성결장염발병중적상호관계。방법 UC환자60례，기중활동조（n=41），완해조（n=19）,병취동기건강체검자（n=20）작위대조조；취청신공복혈액이검측기NO、P-selectin、백세포（WBC）、혈소판（ PLT）수평。결과 UC활동조적혈청중NO、P-selectin수평명현고우완해조화대조조，차이균구유현저성（P＜0.01）,이완해조、대조조량조간무통계학차이（P＞0.05），지유활동조중P-selectin여NO적표체존재정상관성（r=0.51,P＜0.01）。UC활동조혈청중WBC、PLT수평명현고우대조조급완해조（P＜0.01）。결론재UC질병적발병중,P-selectin여NO가능유협동작용。
Objective To explore the correlation between serum nitricoxide (NO) and P-selectin in the pathogenic process of ulcer-ative colitis (UC). Methods 60 cases with UC were enrolled, 41 in active group and 19 in remission group, and 20 healthy normal were chosen to be control group;the levels of NO, P-selectin, WBC and PLT in fasting blood were detected. Results The levels of serum NO and P-selectin of the cases in active group were much higher than those of the cases in remission group and control group, the difference was of significance (P<0.01) while there existed no statistical difference between remission group and control group (P>0.05);the ex-pressions of NO and P-selectin were positively correlated in active group (r=0.51, P<0.01);the levels of WBC and PLT were much high-er than those in remission group and control group (P<0.01). Conclusions P-selectin and NO may have a synergistic effect in the patho-genic process of UC.