CAJ | 학술논문

以聚乙烯醇（PVA ）和丙烯酸（AA）为原料，过硫酸铵（APS）为引发剂，N ，N′-亚甲基双丙烯酰胺（MBA）为交联剂，通过化学引发聚合制备了具有互穿网络结构的聚乙烯醇/丙烯酸（PVA/PAA ）水凝胶．用红外光谱（FT-IR）、热重分析（TG-DTA）、扫描电镜（SEM）对其结构、热稳定性和形貌进行了表征．研究了溶胀动力学，探讨了pH及盐浓度对水凝胶溶胀性能的影响，考察了该凝胶在不同pH介质中对药物异烟肼的控制释放行为．结果表明， PVA/PAA水凝胶具有良好的pH敏感性和离子强度敏感性，其在pH＝1.20的缓冲溶液中对异烟肼的累积释放率明显大于在pH＝7.40和p H＝6.86的缓冲溶液中．
이취을희순（PVA ）화병희산（AA）위원료，과류산안（APS）위인발제，N ，N′-아갑기쌍병희선알（MBA）위교련제，통과화학인발취합제비료구유호천망락결구적취을희순/병희산（PVA/PAA ）수응효．용홍외광보（FT-IR）、열중분석（TG-DTA）、소묘전경（SEM）대기결구、열은정성화형모진행료표정．연구료용창동역학，탐토료pH급염농도대수응효용창성능적영향，고찰료해응효재불동pH개질중대약물이연정적공제석방행위．결과표명， PVA/PAA수응효구유량호적pH민감성화리자강도민감성，기재pH＝1.20적완충용액중대이연정적루적석방솔명현대우재pH＝7.40화p H＝6.86적완충용액중．
A series of polyvinyl alcohol/poly (acrylic acid )(PVA/PVA ) hydrogels with interpenetrating network(IPN) are prepared by polymerization of polyvinyl alcohol and acrylic acid using (NH4 )2 S2 O8 as the initiator and N ,N′-methylenebis(acrylamide) as the crosslinking agent . The samples are characterized by FT-IR , TG-DTA and SEM . The swelling properties are studied . The effects of ionic intensity and pH values on the swelling ratio are also investigated . In addition , the characteristic for drug delivery is studied using isonicotinyl hydrazide(INH) as the model drug in different pH buffer solutions . The results show that PVA/PAA hydrogels have good sensitivity for pH values and ionic strength . The cumulative release rate of the hydrogels in the pH =1.20 buffer solution is significantly more than w hich in the pH =7.40 and pH=6.86 buffer solutions .