神经损伤与功能重建
神經損傷與功能重建
신경손상여공능중건
NEURAL INJURY AND FUNCTIONAL RECONSTRUCTION
2014年
5期
391-394
,共4页
彭凯润%邓兵梅%刘晓燕%杨红军%黎振声%徐习
彭凱潤%鄧兵梅%劉曉燕%楊紅軍%黎振聲%徐習
팽개윤%산병매%류효연%양홍군%려진성%서습
脑梗死%继发损害%丁基苯酞%弥散张量成像%部分各向异性
腦梗死%繼髮損害%丁基苯酞%瀰散張量成像%部分各嚮異性
뇌경사%계발손해%정기분태%미산장량성상%부분각향이성
cerebral infarction%secondary damage%butylphthalide%diffusion tensor imaging%farctional anisotropy
目的：采用磁共振弥散张量成像（DTI）探讨丁基苯酞治疗对脑梗死患者梗死灶远隔部位继发性损害的影响。方法：60例急性脑梗死患者随机分为丁基苯酞组和对照组各30例。2组均给予抗血小板及基础治疗，丁基苯酞组加用丁基苯酞，于治疗前及治疗4周后行美国国立卫生研究院卒中量表（NIHSS）、改良Rankin评分（mRS）及DTI扫描，分别测量梗死灶、梗死同侧大脑脚及对侧相应区域的部分各向异性（FA）值。结果：治疗4周后，2组患者NIHSS和mRS评分均较治疗前降低（＜0.01），丁基苯酞组低于对照组（＜0.05）；2组患者梗死灶及同侧大脑脚水平锥体束的FA值均较治疗前下降（＜0.01），丁基苯酞组的梗死灶、同侧大脑脚FA值均大于对照组（＜0.01）。结论：丁基苯酞可能通过减轻梗死后远隔损害而改善脑梗死患者的神经功能损害。
目的：採用磁共振瀰散張量成像（DTI）探討丁基苯酞治療對腦梗死患者梗死竈遠隔部位繼髮性損害的影響。方法：60例急性腦梗死患者隨機分為丁基苯酞組和對照組各30例。2組均給予抗血小闆及基礎治療，丁基苯酞組加用丁基苯酞，于治療前及治療4週後行美國國立衛生研究院卒中量錶（NIHSS）、改良Rankin評分（mRS）及DTI掃描，分彆測量梗死竈、梗死同側大腦腳及對側相應區域的部分各嚮異性（FA）值。結果：治療4週後，2組患者NIHSS和mRS評分均較治療前降低（＜0.01），丁基苯酞組低于對照組（＜0.05）；2組患者梗死竈及同側大腦腳水平錐體束的FA值均較治療前下降（＜0.01），丁基苯酞組的梗死竈、同側大腦腳FA值均大于對照組（＜0.01）。結論：丁基苯酞可能通過減輕梗死後遠隔損害而改善腦梗死患者的神經功能損害。
목적：채용자공진미산장량성상（DTI）탐토정기분태치료대뇌경사환자경사조원격부위계발성손해적영향。방법：60례급성뇌경사환자수궤분위정기분태조화대조조각30례。2조균급여항혈소판급기출치료，정기분태조가용정기분태，우치료전급치료4주후행미국국립위생연구원졸중량표（NIHSS）、개량Rankin평분（mRS）급DTI소묘，분별측량경사조、경사동측대뇌각급대측상응구역적부분각향이성（FA）치。결과：치료4주후，2조환자NIHSS화mRS평분균교치료전강저（＜0.01），정기분태조저우대조조（＜0.05）；2조환자경사조급동측대뇌각수평추체속적FA치균교치료전하강（＜0.01），정기분태조적경사조、동측대뇌각FA치균대우대조조（＜0.01）。결론：정기분태가능통과감경경사후원격손해이개선뇌경사환자적신경공능손해。
Objective:To study the effects of butylphthalide on secondary damage in area remote from cerebral infarction by diffusion tensor imaging (DTI). Methods:Sixty patients with acute cerebral infarction were randomly divided into groups of butylphthalide and control (n=30 in each group). Both groups were given basement treatment, and the butylphthalide group were given butylphthalide additionally. The 2 groups had DTI inspections respectively before and after treatment. Then the FA values of the infarctions, ipsilateral cerebral peduncle and corresponding contralateral regions were measured. The National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Sclae (mRS) were used to evaluate the neurological function. Result:After 4-weeks treatment, the scores of NIHSS and mRS were decreased in two groups ( <0. 01). However, the score of butylphthalide group was decreased significantly compared to control group ( <0.05). Both the FA value of cerebral infarction lesions and corticospinal tract in the cerebral peduncle of the 2 groups were decreased after treatment, and the FA value of the infarction lesion and the ipsilateral cerebral peduncle of the butylphthalide group was significantly higher than that of control group ( <0.01). Conclusion:Butylphthalide could relieve secondary damage in area remote from cerebral infarction, and then improve the prognosis of the patients of cerebral infarction.
