全科医学临床与教育
全科醫學臨床與教育
전과의학림상여교육
CLINICAL EDUCATION OF GENERAL PRACTICE
2014年
5期
501-503
,共3页
妊娠高血压疾病%胎球蛋白-A%超敏C反应蛋白
妊娠高血壓疾病%胎毬蛋白-A%超敏C反應蛋白
임신고혈압질병%태구단백-A%초민C반응단백
pregnancy induced hypertension%fetuin-A%high sensitive C-reactive protein
目的：检测妊娠高血压疾病患者血清胎球蛋白-A（FA）和超敏C反应蛋白（hsCRP）的水平，探讨FA与妊娠高血压疾病发病的关系。方法选择妊娠高血压疾病组93例（子痫前期轻度组30例、子痫前期重度组31例、子痫期组32例），正常妊娠组30例，测定其血清中FA和hsCRP浓度，同时测定胰岛素抵抗指数和血脂，分析血清FA水平与hsCRP和HOMA-IR等的相关性。结果子痫前期轻度组、子痫前期重度组和子痫期组的血清FA、hsCRP水平均明显高于正常妊娠组，差异均有统计学意义（q分别=2.81、2.74、2.55；2.11、2.23、2.52，P均＜0.05），子痫期组、子痫前期重度组的FA和hsCRP均明显高于子痫前期轻度组，差异均有统计学意义（q分别=3.11、2.89、2.95、3.02， P均＜0.05）；子痫期组FA和hsCRP均明显高于子痫前期重度组，差异均有统计学意义（q分别=3.34、3.09， P均＜0.05）；妊娠高血压疾病患者血清FA水平与血清hsCRP和HOMA-IR呈正相关（r分别=0.39、0.27， P均＜0.05）。结论血清FA水平在妊娠高血压疾病患者中明显增高，与病情严重程度有关，同时FA与hsCRP水平和HOMA-IR呈正相关，提示血清FA水平可作为临床观察妊娠高血压疾病的重要指标。
目的：檢測妊娠高血壓疾病患者血清胎毬蛋白-A（FA）和超敏C反應蛋白（hsCRP）的水平，探討FA與妊娠高血壓疾病髮病的關繫。方法選擇妊娠高血壓疾病組93例（子癇前期輕度組30例、子癇前期重度組31例、子癇期組32例），正常妊娠組30例，測定其血清中FA和hsCRP濃度，同時測定胰島素牴抗指數和血脂，分析血清FA水平與hsCRP和HOMA-IR等的相關性。結果子癇前期輕度組、子癇前期重度組和子癇期組的血清FA、hsCRP水平均明顯高于正常妊娠組，差異均有統計學意義（q分彆=2.81、2.74、2.55；2.11、2.23、2.52，P均＜0.05），子癇期組、子癇前期重度組的FA和hsCRP均明顯高于子癇前期輕度組，差異均有統計學意義（q分彆=3.11、2.89、2.95、3.02， P均＜0.05）；子癇期組FA和hsCRP均明顯高于子癇前期重度組，差異均有統計學意義（q分彆=3.34、3.09， P均＜0.05）；妊娠高血壓疾病患者血清FA水平與血清hsCRP和HOMA-IR呈正相關（r分彆=0.39、0.27， P均＜0.05）。結論血清FA水平在妊娠高血壓疾病患者中明顯增高，與病情嚴重程度有關，同時FA與hsCRP水平和HOMA-IR呈正相關，提示血清FA水平可作為臨床觀察妊娠高血壓疾病的重要指標。
목적：검측임신고혈압질병환자혈청태구단백-A（FA）화초민C반응단백（hsCRP）적수평，탐토FA여임신고혈압질병발병적관계。방법선택임신고혈압질병조93례（자간전기경도조30례、자간전기중도조31례、자간기조32례），정상임신조30례，측정기혈청중FA화hsCRP농도，동시측정이도소저항지수화혈지，분석혈청FA수평여hsCRP화HOMA-IR등적상관성。결과자간전기경도조、자간전기중도조화자간기조적혈청FA、hsCRP수평균명현고우정상임신조，차이균유통계학의의（q분별=2.81、2.74、2.55；2.11、2.23、2.52，P균＜0.05），자간기조、자간전기중도조적FA화hsCRP균명현고우자간전기경도조，차이균유통계학의의（q분별=3.11、2.89、2.95、3.02， P균＜0.05）；자간기조FA화hsCRP균명현고우자간전기중도조，차이균유통계학의의（q분별=3.34、3.09， P균＜0.05）；임신고혈압질병환자혈청FA수평여혈청hsCRP화HOMA-IR정정상관（r분별=0.39、0.27， P균＜0.05）。결론혈청FA수평재임신고혈압질병환자중명현증고，여병정엄중정도유관，동시FA여hsCRP수평화HOMA-IR정정상관，제시혈청FA수평가작위림상관찰임신고혈압질병적중요지표。
Objective To detect the level of serum fetuin-A and hsCRP in patients with gestational hypertension and explore the relationship between FA and the incidence of gestational hypertension. Methods Ninety-three patients with gestational hypertension including 30 cases of mild preeclampsia, 31 cases of severe preeclampsia and 32 cases of eclamp-sia were selected as well as 30 cases of normal pregnancy. Serum levels of FA, hsCRP, HOMA-IR and blood lipid were measured and the relationships among them were analyzed. Results The FA level of mild preeclampsia group, severe preeclampsia group and eclampsia group were significantly higher than those of normal pregnancy (q=2.81,2.74,2.55,P<0.05) as well as hsCRP level (q=2.11,2.23,2.52,P<0.05). The FA and hsCRP levels of eclampsia group and severe preeclampsia group were significantly higher than those of mild preeclampsia group (q=3.11,2.89,2.95,3.02,P<0.05). The FA and hsCRP levels of severe preeclampsia group were significantly higher than those of eclampsia group (q=3.34,3.09, P<0.05). The FA were positively related with hsCRP and HOMA-IR (r=0.39,0.27,P<0.05). Conclusions Serum FA levels in gestational hypertension is significantly increased with the disease severity. The FA levels were positively related with hsCRP and HOMA-IR which suggested that serum FA level can be used as clinical observation indicator of gestational hypertension.
