中国临床保健杂志
中國臨床保健雜誌
중국림상보건잡지
CHINESE JOURNAL OF CLINICAL HEALTHCARE
2014年
5期
475-477
,共3页
轻度认知障碍%患病率%半胱氨酸%叶酸
輕度認知障礙%患病率%半胱氨痠%葉痠
경도인지장애%환병솔%반광안산%협산
Mild cognitive impairment%Morbidity%Cysteine%Folic acid
目的:对合肥地区轻度认知功能障碍(MCI)患病情况进行流行病学调查,并观察叶酸对 MCI的干预治疗效果。方法调查合肥地区多所医院就诊的679名患者的 MMSE 值和血清同型半胱氨酸(Hcy)水平,根据简易精神状态评价量表(MMSE)评分值分为正常老年组(A 组),轻度认知功能障碍组(B 组)及痴呆组(C 组),其中 B 组根据有无叶酸治疗,分为治疗组(B1组)和非治疗组(B2组)。观察 A 组、B1组及 B2组患者的 MMSE 值变化及 Hcy 值,随访时间为3年。结果679名老年人中,其中正常老年人560人,MCI92人,痴呆者27人。随访期内,A 组47例新发 MCI,B1组10例、B2组16例新发痴呆。MCI 患者未予干预组3年内有36.36%进展为痴呆;叶酸干预组痴呆三年患病率为20.83%。结论合肥地区60岁以上的老人 MCI和痴呆患病率较高,补充叶酸可延缓 MCI 患者病情进展。
目的:對閤肥地區輕度認知功能障礙(MCI)患病情況進行流行病學調查,併觀察葉痠對 MCI的榦預治療效果。方法調查閤肥地區多所醫院就診的679名患者的 MMSE 值和血清同型半胱氨痠(Hcy)水平,根據簡易精神狀態評價量錶(MMSE)評分值分為正常老年組(A 組),輕度認知功能障礙組(B 組)及癡呆組(C 組),其中 B 組根據有無葉痠治療,分為治療組(B1組)和非治療組(B2組)。觀察 A 組、B1組及 B2組患者的 MMSE 值變化及 Hcy 值,隨訪時間為3年。結果679名老年人中,其中正常老年人560人,MCI92人,癡呆者27人。隨訪期內,A 組47例新髮 MCI,B1組10例、B2組16例新髮癡呆。MCI 患者未予榦預組3年內有36.36%進展為癡呆;葉痠榦預組癡呆三年患病率為20.83%。結論閤肥地區60歲以上的老人 MCI和癡呆患病率較高,補充葉痠可延緩 MCI 患者病情進展。
목적:대합비지구경도인지공능장애(MCI)환병정황진행류행병학조사,병관찰협산대 MCI적간예치료효과。방법조사합비지구다소의원취진적679명환자적 MMSE 치화혈청동형반광안산(Hcy)수평,근거간역정신상태평개량표(MMSE)평분치분위정상노년조(A 조),경도인지공능장애조(B 조)급치태조(C 조),기중 B 조근거유무협산치료,분위치료조(B1조)화비치료조(B2조)。관찰 A 조、B1조급 B2조환자적 MMSE 치변화급 Hcy 치,수방시간위3년。결과679명노년인중,기중정상노년인560인,MCI92인,치태자27인。수방기내,A 조47례신발 MCI,B1조10례、B2조16례신발치태。MCI 환자미여간예조3년내유36.36%진전위치태;협산간예조치태삼년환병솔위20.83%。결론합비지구60세이상적노인 MCI화치태환병솔교고,보충협산가연완 MCI 환자병정진전。
Objective To investigate the prevalence of mild cognitive impairment (MCI)in hefei,and ob-serve the intervention effect of folic acid for MCI .Method Six hundreds and seventy nine patients were selected from multiple hospital according MMSE and the level of homocysteine.On the basis of MMSE scores,the patients were divided into normal group(A),MCI group(B)and dementia group(C).The MCI group was divided into the treatment group(B1 )and non -treatment group(B2).The MMSE value and Hcy levels were follow -up three years. Results Six hundreds and seventy nine elderly people were surveyed,including 560 normal elderly,92 MCI and 27 dementia patients.Forty -seven new cases of MCI were detected in group A .Ten and sixteen new cases of dementia were developed from MCI in B1 and B2 group.The 36.36% MCI patients were developed into dementia in control group,and 20.83% MCI patients were developed into dementia in intervention group after 3 years.Conclusion The prevalence of MCI and dementia are higher in Hefei elderly.The supplementation of folic acid can retard the pro-gress of MCI.