中华生物医学工程杂志
中華生物醫學工程雜誌
중화생물의학공정잡지
CHINESE JOURNAL OF BIOMEDICAL ENGINEERING
2013年
5期
394-396
,共3页
结直肠肿瘤%癌胚抗原%CA-19-9抗原%CA242抗原
結直腸腫瘤%癌胚抗原%CA-19-9抗原%CA242抗原
결직장종류%암배항원%CA-19-9항원%CA242항원
Colorectal neoplasms%Carcinoembryonic antigen%CA-19-9 antigen%CA242 antigen
目的 研究血清肿瘤标志物联合检测在结直肠癌患者诊断中的应用价值.方法 收集2010年1月至2012年9月河北医科大学第三医院肛肠科收治的120例结直肠癌患者作为观察组,80例结直肠良性疾病患者作为良性对照组,100例健康体检者作为健康对照组,采用全自动电化学发光仪检测各组患者外周血中癌胚抗原(CEA)、糖类抗原(CA)199和CA242的含量.对比观察组不同TNM分期患者之间外周血CEA、CA199和CA242水平;分析3项指标联合检测诊断结直肠癌的灵敏度和特异度.结果 观察组患者CEA、CA199和CA242水平明显高于良性对照组和健康对照组,并且在观察组患者3项指标水平均为TNM Ⅰ期＞Ⅱ期＞Ⅲ期＞Ⅳ期.3项指标联合检查灵敏度为80.00％,特异度为97.78％,均高于3项指标单独检测(灵敏度和特异度分别为CEA:17.50％、73.89％,CA199:29.17％、67.22％,CA242:71.67％、68.89％,均P＜0.05).结论 CEA、CA199和CA242联合检查能提高结直肠癌诊断的灵敏度和特异度,具有积极的临床价值.
目的 研究血清腫瘤標誌物聯閤檢測在結直腸癌患者診斷中的應用價值.方法 收集2010年1月至2012年9月河北醫科大學第三醫院肛腸科收治的120例結直腸癌患者作為觀察組,80例結直腸良性疾病患者作為良性對照組,100例健康體檢者作為健康對照組,採用全自動電化學髮光儀檢測各組患者外週血中癌胚抗原(CEA)、糖類抗原(CA)199和CA242的含量.對比觀察組不同TNM分期患者之間外週血CEA、CA199和CA242水平;分析3項指標聯閤檢測診斷結直腸癌的靈敏度和特異度.結果 觀察組患者CEA、CA199和CA242水平明顯高于良性對照組和健康對照組,併且在觀察組患者3項指標水平均為TNM Ⅰ期＞Ⅱ期＞Ⅲ期＞Ⅳ期.3項指標聯閤檢查靈敏度為80.00％,特異度為97.78％,均高于3項指標單獨檢測(靈敏度和特異度分彆為CEA:17.50％、73.89％,CA199:29.17％、67.22％,CA242:71.67％、68.89％,均P＜0.05).結論 CEA、CA199和CA242聯閤檢查能提高結直腸癌診斷的靈敏度和特異度,具有積極的臨床價值.
목적 연구혈청종류표지물연합검측재결직장암환자진단중적응용개치.방법 수집2010년1월지2012년9월하북의과대학제삼의원항장과수치적120례결직장암환자작위관찰조,80례결직장량성질병환자작위량성대조조,100례건강체검자작위건강대조조,채용전자동전화학발광의검측각조환자외주혈중암배항원(CEA)、당류항원(CA)199화CA242적함량.대비관찰조불동TNM분기환자지간외주혈CEA、CA199화CA242수평;분석3항지표연합검측진단결직장암적령민도화특이도.결과 관찰조환자CEA、CA199화CA242수평명현고우량성대조조화건강대조조,병차재관찰조환자3항지표수평균위TNM Ⅰ기＞Ⅱ기＞Ⅲ기＞Ⅳ기.3항지표연합검사령민도위80.00％,특이도위97.78％,균고우3항지표단독검측(령민도화특이도분별위CEA:17.50％、73.89％,CA199:29.17％、67.22％,CA242:71.67％、68.89％,균P＜0.05).결론 CEA、CA199화CA242연합검사능제고결직장암진단적령민도화특이도,구유적겁적림상개치.
Objective To study the diagnostic value of combined detection of three serum tumor markers in patients with colorectal cancer.Methods Between January 2010 and September 2012,120 patients with colorectal cancer in the Third Hospital,Hebei Medical University (observation group),80 patients with benign colorectal diseases (benign control group) and 100 individuals who underwent health check-up (healthy control group) were recruited.The Roche Elecsys 2010 automatic electrochemical luminescence instrument was employed to detect the levels of carcinoembryonic antigen (CEA),carbohydrate antigen(CA) 199 and CA242 in peripheral blood,which entailed comparison on the difference among various TNM stages and analysis of the assay sensitivity and specificity of their combination.Results The observation group yielded significantly higher levels of CEA,CA199 and CA242 compared with benign and healthy control group.The levels of these indices followed the order of TNM Ⅰ,Ⅱ,Ⅲ and Ⅳ respectively,based on the staging.The combination of three indices yielded the assay sensitivity and specificity of 80.00％ and 97.78％,which were higher than those of either parameter alone (CEA:17.50％ and 73.89％,CA199:29.17％ and 67.22％,CA242:71.67％ and 68.89％,all P＜0.05).Conclusion The combined detection of CEA,CA199 and CA242 improves the assay sensitivity and specificity of colorectal cancer and is worthwhile for clinical practice.
