CAJ | 학술논문

目的：观察复配型醋酸氯己定抑菌剂、醋酸氯己定抑菌剂及单纯中药抑菌剂的抑菌效果及毒性。方法采用动物实验和琼脂扩散法对3种抑菌剂进行抑菌效果及毒性测定。结果复配型醋酸氯己定抑菌剂和醋酸氯己定抑菌剂对金黄色葡萄球菌、大肠杆菌和白色念珠菌的抑菌圈直径比单纯中药抑菌剂的抑菌圈直径增加1倍左右，复配型醋酸氯己定抑菌剂和中药抑菌剂动物毒性试验无刺激，醋酸氯己定抑菌剂有轻度眼刺激。结论复配型醋酸氯己定抑菌剂抑菌效果显著强于中药抑菌剂，其毒性低于醋酸氯己定抑菌剂。
목적：관찰복배형작산록기정억균제、작산록기정억균제급단순중약억균제적억균효과급독성。방법채용동물실험화경지확산법대3충억균제진행억균효과급독성측정。결과복배형작산록기정억균제화작산록기정억균제대금황색포도구균、대장간균화백색념주균적억균권직경비단순중약억균제적억균권직경증가1배좌우，복배형작산록기정억균제화중약억균제동물독성시험무자격，작산록기정억균제유경도안자격。결론복배형작산록기정억균제억균효과현저강우중약억균제，기독성저우작산록기정억균제。
Objective To observe the bacteriostatic efficacy and toxicity of three kinds of bacteriostatic agents .Methods The ani-mal test and agar diffusion method were applied to determine the inhibition effect and toxicity of three kinds of bacteriostatic agents .Results The antibacterial circle diameter of compound chlorhexidine acetate and chlorhexidine acetate for Staphylococcus aureus ,Escherichia coli and Candida albicans increased by 1 time compared with single Chinese medicine bacteriostatic agent .Compound chlorhexidine acetate and single traditional Chinese medicine bacteriostatic agent had no stimulation in animal toxicity test ,while chlorhexidine acetate had mild eye irritation . Conclusion Compared with the traditional Chinese medicine bacteriostatic agent , antibacterial effect of compound chlorhexidine acetate group enhances significantly ,and its toxicity is lower than that of chlorhexidine acetate .