CAJ | 학술논문

目的探讨甲状腺功能减低症(甲减)与习惯性流产的关系及其相关的病理机制。方法将笔者所在医院2008年8月~2013年8月收治的160例习惯性流产患者分为甲减组和对照组，对照组采用小剂量阿司匹林及低分子肝素治疗，甲减组在对照组的基础上采用左旋甲状腺素治疗，比较两组患者的治疗效果。结果甲减组的患者在基础治疗上及时给予左旋甲状腺素替代治疗，疗效显著，其流产率、足月产、活产率、分娩孕周和抗体清除率均与对照组无统计学差异。结论妊娠早期甲状腺功能筛查和治疗具有非常重要的临床意义，早期甲状腺替代治疗能够降低流产率。
목적탐토갑상선공능감저증(갑감)여습관성유산적관계급기상관적병리궤제。방법장필자소재의원2008년8월~2013년8월수치적160례습관성유산환자분위갑감조화대조조，대조조채용소제량아사필림급저분자간소치료，갑감조재대조조적기출상채용좌선갑상선소치료，비교량조환자적치료효과。결과갑감조적환자재기출치료상급시급여좌선갑상선소체대치료，료효현저，기유산솔、족월산、활산솔、분면잉주화항체청제솔균여대조조무통계학차이。결론임신조기갑상선공능사사화치료구유비상중요적림상의의，조기갑상선체대치료능구강저유산솔。
Objective To investigate the reduction in thyroid function (hypothyroidism) relationship with habitual abortion and the pathogenesis related. Methods The hospital 2008 August~2013 year in August 160 cases of habitual abortion were divided into hypothyroidism group and control group, control group with smal dose of aspirin and low molecular weight heparin, hypothyroidism group with L-thyroxine treatment on the basis of the control group, compared two groups of patients the treatment ef ect. Results Hypothyroidism group in the basic treatment timely levothyroxine replacement therapy, curative effect is distinct, the abortion rate, live birth rate, term birth, gestational age and antibody clearance were not statistical y dif erent from the control group. Conclusion Early pregnancy thyroid function screening and treatment has very important clinical significance, early thyroid replacement therapy can reduce the abortion rate.