医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2013年
11期
328-328
,共1页
曲美他嗪%心肌桥%心肌缺血
麯美他嗪%心肌橋%心肌缺血
곡미타진%심기교%심기결혈
Trimetazidine%Myocardial bridge%Myocardial ischemia
目的观察曲美他嗪对冠状动脉心肌桥的疗效。方法将平板心电图运动负荷试验阳性，经冠状动脉造影确诊心肌桥的患者50例随机分为曲美他嗪治疗组和常规治疗组。常规治疗组予美托洛尔片口服，曲美他嗪治疗组在常规治疗基础上加用曲美他嗪20mg 3次/d口服。治疗3月后两组再次行运动负荷试验，比较治疗前后运动负荷试验阳性率变化以及治疗后两组间阳性率的差异。结果曲美他嗪组治疗后运动负荷试验阳性率较治疗前显著下降（16.0%vs 100.0%，P=0.000），与常规组相比，阳性率同样显著下降（16.0%vs 44.0%P=0.031）。结论曲美他嗪联合常规药物能有效缓解冠状动脉心肌桥患者的心肌缺血。
目的觀察麯美他嗪對冠狀動脈心肌橋的療效。方法將平闆心電圖運動負荷試驗暘性，經冠狀動脈造影確診心肌橋的患者50例隨機分為麯美他嗪治療組和常規治療組。常規治療組予美託洛爾片口服，麯美他嗪治療組在常規治療基礎上加用麯美他嗪20mg 3次/d口服。治療3月後兩組再次行運動負荷試驗，比較治療前後運動負荷試驗暘性率變化以及治療後兩組間暘性率的差異。結果麯美他嗪組治療後運動負荷試驗暘性率較治療前顯著下降（16.0%vs 100.0%，P=0.000），與常規組相比，暘性率同樣顯著下降（16.0%vs 44.0%P=0.031）。結論麯美他嗪聯閤常規藥物能有效緩解冠狀動脈心肌橋患者的心肌缺血。
목적관찰곡미타진대관상동맥심기교적료효。방법장평판심전도운동부하시험양성，경관상동맥조영학진심기교적환자50례수궤분위곡미타진치료조화상규치료조。상규치료조여미탁락이편구복，곡미타진치료조재상규치료기출상가용곡미타진20mg 3차/d구복。치료3월후량조재차행운동부하시험，비교치료전후운동부하시험양성솔변화이급치료후량조간양성솔적차이。결과곡미타진조치료후운동부하시험양성솔교치료전현저하강（16.0%vs 100.0%，P=0.000），여상규조상비，양성솔동양현저하강（16.0%vs 44.0%P=0.031）。결론곡미타진연합상규약물능유효완해관상동맥심기교환자적심기결혈。
Objective To observe the ef ect of trimetazidine on coronary myocardial bridge.Methods 50 patients diagnosed as coronary myocardial bridge with positive results of treadmil exercise testing (TET)were randomized into standard therapy group and trimetazidine group.Patients in standard therapy group were treated with metoprolol,while patiens in trimetazidine group were added trimetazidine in addition to standard therapy.Three months after treatment,TET were tested again,and the positive rates were compared.Results Significant decrease in the positive rates of TET were observed in trimetazidine group when compared with treatment before(16.0%vs 100.0%,P=0.000)and compared with standard therapy (16.0% vs 44.0% P=0.031).Conclusion Trimetazidine combined with standard therapy can ef ectively relieve myocardial ischemia in patients with coronary myocardial bridge.
