CAJ | 학술논문

肺动脉高压是一种常见的临床综合征，以肺动脉压力升高为特征，其病理机制主要包括肺动脉血管收缩、原位血栓形成及肺血管重塑。肺动脉平滑肌细胞是构成肺动脉血管重塑的主要病理基础。因此，探讨肺动脉平滑肌细胞增殖的分子机制并进行相关干预研究，是治疗肺动脉高压的关键策略。本文综述了与肺动脉平滑肌细胞增殖有关的主要分子信号通路。
폐동맥고압시일충상견적림상종합정，이폐동맥압력승고위특정，기병리궤제주요포괄폐동맥혈관수축、원위혈전형성급폐혈관중소。폐동맥평활기세포시구성폐동맥혈관중소적주요병리기출。인차，탐토폐동맥평활기세포증식적분자궤제병진행상관간예연구，시치료폐동맥고압적관건책략。본문종술료여폐동맥평활기세포증식유관적주요분자신호통로。
Pulmonary hypertension (PAH) is a common clinical syndrome characterized by elevated pulmonary arterial pressure. The pathological changes in PAH include increased vasoconstrictor tone, thrombosis in situ and pulmonary vascular remodeling. Pulmonary arterial smooth muscle cell (PASMC) proliferation is a hallmark of pulmonary vascular remodeling, and exploration of the molecular mechanisms of PASMC proliferation and intervention of the involved signaling pathways is therefore of great importance for prevention and treatment of PAH. This review focus primarily on the current understanding of the molecular mechanisms involved in the proliferation of PASMCs.