CAJ | 학술논문

细胞死亡是生命活动过程中一项重要的生理或病理现象。传统的细胞死亡方式主要包括凋亡、坏死和自噬等。新近研究发现了一种新的细胞死亡方式-methuosis，在这种细胞死亡过程中，由于过度刺激导致细胞内水泡吸收、积累、融合而逐步形成相对于细胞本身而言的大量巨大液泡，最终导致细胞代谢活动减少、细胞膜破裂、细胞死亡。本文对巨泡式死亡的命名来源、形态特征、可能的机制、与相关死亡方式的区别及其研究进展进行了阐述。
세포사망시생명활동과정중일항중요적생리혹병리현상。전통적세포사망방식주요포괄조망、배사화자서등。신근연구발현료일충신적세포사망방식-methuosis，재저충세포사망과정중，유우과도자격도치세포내수포흡수、적루、융합이축보형성상대우세포본신이언적대량거대액포，최종도치세포대사활동감소、세포막파렬、세포사망。본문대거포식사망적명명래원、형태특정、가능적궤제、여상관사망방식적구별급기연구진전진행료천술。
Cell death is a major physiological or pathological phenomenon in life activities. The classic forms of cell death include apoptosis, necrosis, and autophagy. Recently, a novel type of cell death has been observed and termed as methuosis, in which excessive stimuli can induce cytoplasmic uptake and accumulation of small bubbles that gradually merge into giant vacuoles, eventually leading to decreased cellular metabolic activity, cell membrane rupture and cell death. In this article, we describe the nomenclature, morphological characteristics and underlying mechanisms of methuosis, compare methuosis with autophagy, oncosis and paraptosis, and review the related researches.