CAJ | 학술논문

目的：探讨奥美拉唑对喉软化患儿食管动力学的影响，为该病的治疗提供依据。方法选取2009年4月-2013年2月于该院进行治疗的46例喉软化患儿为研究对象，将其随机分为对照组（常规方案治疗组）23例和观察组（常规方案加奥美拉唑治疗组）23例，然后将两组治疗6、12周的总有效率与治疗前后的食管动力学指标进行统计及比较。结果观察组治疗6、12周的总有效率分别高于对照组，治疗后的食管动力学指标也明显好于对照组，均P＜0．05，有显著性差异。结论奥美拉唑对喉软化患儿食管动力学的影响较大，有助于患儿疾病治疗效果的改善。
목적：탐토오미랍서대후연화환인식관동역학적영향，위해병적치료제공의거。방법선취2009년4월-2013년2월우해원진행치료적46례후연화환인위연구대상，장기수궤분위대조조（상규방안치료조）23례화관찰조（상규방안가오미랍서치료조）23례，연후장량조치료6、12주적총유효솔여치료전후적식관동역학지표진행통계급비교。결과관찰조치료6、12주적총유효솔분별고우대조조，치료후적식관동역학지표야명현호우대조조，균P＜0．05，유현저성차이。결론오미랍서대후연화환인식관동역학적영향교대，유조우환인질병치료효과적개선。
Objective To study the influence of omeprazole on the sophageal dynamics of children with laryngomalacia ,in order to pro-vide evidence for the treatment .Methods Forty-six children with laryngomalacia admitted to Shenzhen Children ’ s Hospital from April 2009 to February 2013 were selected as research objects ,and were randomly assigned into control group ( conventional therapy group ,n=23) and observation group(conventional therapy plus omeprazole group ,n=23).The total effective rate at 6 th and 12 th week after the treatment and sophageal dynamics indexes before and after the treatment of two groups were analyzed and compared .Results The total effective rates of observation group at 6 th and 12 th week after the treatment were respectively higher than those of control group , and sophageal dynamics indexes of observation group after the treatment were obviously better than those of control group (P<0.05), both with significant differences .Conclusions The influence of omeprazole on the sophageal dynamics of children with laryngomalacia is great,and it is helpful for the improvement of treatment effect of children .